PDLIM7 and SH2B2

Number of citations of the paper that reports this interaction (PMID 15946664)
9

Data Source:
HPRD (two hybrid, in vivo)

		PDLIM7	SH2B2
Gene Name		PDZ and LIM domain 7 (enigma)	SH2B adaptor protein 2
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Nucleus Cytoplasm Focal Adhesion Actin Cytoskeleton	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Identical Protein Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Multicellular Organismal Development Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Osteoblast Differentiation	B-1 B Cell Homeostasis Signal Transduction Nervous System Development Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of JAK-STAT Cascade Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway Brown Fat Cell Differentiation
Pathways			Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: AP5B1 BSG C20orf195 CCDC185 DGCR6 ENKD1 GEM GFAP HNRNPD IQGAP1 MDM2 PAK7 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	21 interactors: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK
Entrez ID		9260	10603
HPRD ID		10436	16097
Ensembl ID		ENSG00000196923
Uniprot IDs		Q9NR12	O14492
PDB IDs		2Q3G	1Q2H
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Death Death Response To Organic Substance Immune System Process Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Histone H3-T6 Phosphorylation Apoptotic Process Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Protein Catabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Death Blood Coagulation Cellular Protein Modification Process Negative Regulation Of Programmed Cell Death Hemostasis Regulation Of Cellular Process Regulation Of Establishment Of Protein Localization Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Peptidyl-amino Acid Modification Positive Regulation Of Signal Transduction Response To Organic Substance Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Innate Immune Response Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Proliferation Regulation Of Immune Response Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Signaling Neurotrophin TRK Receptor Signaling Pathway Defense Response Cell Communication Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Phosphorylation Response To Growth Factor Movement Of Cell Or Subcellular Component Response To Peptide Hormone Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell Activation Response To Peptide Response To Wounding Immune Response Regulation Of Immune System Process Cellular Response To Stimulus
Tagcloud ?			accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl
Tagcloud (Difference) ?			accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl
Tagcloud (Intersection) ?