PAK5 and ARHGEF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAK5	ARHGEF19
Description		p21 (RAC1) activated kinase 5	Rho guanine nucleotide exchange factor 19
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Membrane Synapse	Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Actin Cytoskeleton Organization Wound Healing Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Alanine aminotransferase levels ( 33339817 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Facial morphology ( 31763980) Gamma glutamyl transferase levels ( 29403010 33339817) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		36 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MARK2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 SRSF11 TSGA10 TUBGCP4 UXT	3 interacting genes: KLHL20 PAK5 RHOA
Entrez ID		57144	128272
HPRD ID		06423	10659
Ensembl ID		ENSG00000101349	ENSG00000142632
Uniprot IDs		B0AZM9 Q9P286	B4DN02 Q8IW93
PDB IDs		2F57 8C12	8YR7
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Cytoplasm Wnt Signaling Pathway Microtubule-based Process Microtubule Nucleation Microtubule Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Projection Assembly Spindle Non-canonical Wnt Signaling Pathway Thioesterase Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Centrosome Establishment Or Maintenance Of Cell Polarity Midbrain Dopaminergic Neuron Differentiation Cellular Component Assembly GTP-dependent Protein Binding Cytoplasmic Ribonucleoprotein Granule Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Tau-protein Kinase Activity Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly	Negative Regulation Of Apoptotic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton Organization Negative Regulation Of Programmed Cell Death Type II Interferon Binding Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Protein K33-linked Ubiquitination Beta Selection Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Bone Trabecula Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Positive Regulation Of Lipase Activity Cleavage Furrow Formation Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Dendrite Heart Valve Formation Endothelial Tube Morphogenesis Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Golgi To Endosome Transport Response To Cytokine Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Response To Peptide Organelle Organization Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity
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