PAK5 and SRSF11

Number of citations of the paper that reports this interaction (PubMedID 36394206)
53

Data Source:
BioGRID (enzymatic study)

		PAK5	SRSF11
Description		p21 (RAC1) activated kinase 5	serine and arginine rich splicing factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Membrane Synapse	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	MRNA Processing RNA Splicing
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		36 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MARK2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 SRSF11 TSGA10 TUBGCP4 UXT	33 interacting genes: ARL6IP4 ATP5F1D CDK6 CSNK2A1 DACH1 DDOST DUSP29 ETS1 GATC HNRNPLL HYI LNX2 MDM2 MEOX2 OGT PAK5 PAX6 PIN1 PUF60 RAB2B RNPS1 SDCBP SREK1 SRPK2 SRRM4 SRSF1 SRSF2 TANK THAP11 TOP1 U2AF2 ZC3HAV1 ZNF385C
Entrez ID		57144	9295
HPRD ID		06423	03599
Ensembl ID		ENSG00000101349	ENSG00000116754
Uniprot IDs		B0AZM9 Q9P286	Q05519 Q5T757 Q5T760
PDB IDs		2F57 8C12
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Cytoplasm Wnt Signaling Pathway Microtubule-based Process Microtubule Nucleation Microtubule Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Projection Assembly Spindle Non-canonical Wnt Signaling Pathway Thioesterase Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Centrosome Establishment Or Maintenance Of Cell Polarity Midbrain Dopaminergic Neuron Differentiation Cellular Component Assembly GTP-dependent Protein Binding Cytoplasmic Ribonucleoprotein Granule Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Tau-protein Kinase Activity Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleic Acid Metabolic Process RNA Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Splicing Regulation Of Cell Motility Regulation Of Locomotion Protein Binding Nuclear Body Organization Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Chromatin DNA Binding Negative Regulation Of Macromolecule Metabolic Process Exon-exon Junction Complex RNA Splicing, Via Transesterification Reactions Positive Regulation Of Type I Interferon Production Sin3-type Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Negative Regulation Of MRNA Metabolic Process Alternative MRNA Splicing, Via Spliceosome
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