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PDLIM7 and PSMF1
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PDLIM7
PSMF1
Gene Name
PDZ and LIM domain 7 (enigma)
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Image
Gene Ontology Annotations
Cellular Component
Stress Fiber
Ruffle
Nucleus
Cytoplasm
Focal Adhesion
Actin Cytoskeleton
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Proteasome Core Complex
Membrane
Molecular Function
Protein Binding
Zinc Ion Binding
Endopeptidase Inhibitor Activity
Protein Binding
Proteasome Binding
Biological Process
Ossification
Receptor-mediated Endocytosis
Multicellular Organismal Development
Actin Cytoskeleton Organization
Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Negative Regulation Of Endopeptidase Activity
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
34 interactors:
AP5B1
BSG
C20orf195
CCDC185
DGCR6
ENKD1
GEM
GFAP
HNRNPD
IQGAP1
MDM2
PAK7
PCBP1
PHF1
PRKCA
PRKCB
PRKCZ
PRKD2
PSMF1
RET
SH2B2
SH3BP2
SMURF1
SPP1
TP53
TPM2
TRAF2
TRAF3
TSG101
UBE2I
UBQLN4
WWP2
ZMYND11
ZNF165
23 interactors:
BEND7
CCDC85B
CD2BP2
CTBP2
DVL3
FBXO7
HOOK2
KHDRBS3
LDOC1
MAGEA11
MIEF2
NUDT21
PAK7
PDLIM7
PSMA7
QKI
RALYL
RBFOX1
RBFOX2
RBMX
RHOXF2
RNF126
TRAF2
Entrez ID
9260
9491
HPRD ID
10436
17919
Ensembl ID
ENSG00000196923
ENSG00000125818
Uniprot IDs
Q9NR12
E7ER20
F5H4Z3
Q5QPM7
Q92530
PDB IDs
2Q3G
2VT8
Enriched GO Terms of Interacting Partners
?
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Intracellular Signal Transduction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Cell Death
Death
Response To Organic Substance
Immune System Process
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Organic Substance
Histone H3-T6 Phosphorylation
Apoptotic Process
Regulation Of Cellular Protein Metabolic Process
Programmed Cell Death
Regulation Of Nitrogen Compound Metabolic Process
Viral Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Regulation Of Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Adhesion
Cellular Response To Growth Factor Stimulus
Regulation Of Apoptotic Process
Protein Modification By Small Protein Conjugation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Protein Catabolic Process
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Signaling
Positive Regulation Of Protein Modification Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Death
Blood Coagulation
Cellular Protein Modification Process
Negative Regulation Of Programmed Cell Death
Hemostasis
Regulation Of Cellular Process
Regulation Of Establishment Of Protein Localization
Cellular Response To Stimulus
Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Receptor Signaling Pathway
Mitotic Cell Cycle Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Splicing
MRNA Processing
MRNA Metabolic Process
RNA Processing
Regulation Of RNA Splicing
Gene Expression
Regulation Of Cellular Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein K63-linked Ubiquitination
Protein Polyubiquitination
RNA Metabolic Process
Regulation Of Gene Expression
MRNA Splicing, Via Spliceosome
Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process
RNA Splicing, Via Transesterification Reactions
Negative Regulation Of Cellular Metabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of MRNA Splicing, Via Spliceosome
Protein Catabolic Process
Positive Regulation Of JUN Kinase Activity
3'-UTR-mediated MRNA Destabilization
Regulation Of Metabolic Process
Neuromuscular Process Controlling Balance
Regulation Of JUN Kinase Activity
Regulation Of MRNA Processing
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Radial Glia Guided Migration Of Purkinje Cell
Regulation Of Definitive Erythrocyte Differentiation
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of JNK Cascade
Positive Regulation Of Chromatin Binding
Non-canonical Wnt Signaling Pathway Via MAPK Cascade
Protein Oligomerization
Neuromuscular Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
MRNA Destabilization
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
RNA Transport
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Tagcloud
?
affymetrix
alanine
alt
aminotransferase
annotation
aspartate
assayed
ast
cideb
cnv
cnvs
copy
dffa
helixtree
kare1
kare2
koreans
netbox
overlapped
programmed
psma3
psmc5
psmc6
psmd12
sdc4
siah1
traits
unrelated
wide
Tagcloud (Difference)
?
affymetrix
alanine
alt
aminotransferase
annotation
aspartate
assayed
ast
cideb
cnv
cnvs
copy
dffa
helixtree
kare1
kare2
koreans
netbox
overlapped
programmed
psma3
psmc5
psmc6
psmd12
sdc4
siah1
traits
unrelated
wide
Tagcloud (Intersection)
?