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PAK7 and EXOSC1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
PAK7
EXOSC1
Gene Name
p21 protein (Cdc42/Rac)-activated kinase 7
exosome component 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Receptor Signaling Protein Serine/threonine Kinase Activity
ATP Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Mitotic Cell Cycle
Protein Phosphorylation
Apoptotic Process
Cytoskeleton Organization
Signal Transduction
Learning
Memory
Locomotory Behavior
Cell Proliferation
Cell Growth
Cell Migration
Signal Transduction By Phosphorylation
Intracellular Signal Transduction
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways
Axon guidance
Activation of Rac
Signaling by Robo receptor
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
20 interactors:
ARMC7
ATPAF2
BAD
CARD9
CCNG1
CDC42
CRBN
EMD
EXOSC1
FAM212A
FHL3
GCC1
LENG1
LZTS2
PDLIM7
PSMF1
RAC1
SORBS3
TUBGCP4
UXT
21 interactors:
A2M
APP
CDC37
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
KCTD1
MAST1
NOS3
NUP160
PAK7
REL
RNF32
TCF4
UPF2
XRN1
Entrez ID
57144
51013
HPRD ID
06423
16223
Ensembl ID
ENSG00000101349
Uniprot IDs
B0AZM9
Q9P286
Q9Y3B2
PDB IDs
2F57
2NN6
Enriched GO Terms of Interacting Partners
?
Cytoskeleton Organization
Organelle Organization
Actin Cytoskeleton Organization
Actin Filament-based Process
Cellular Protein Complex Assembly
Mitotic Cell Cycle Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Mitotic Cell Cycle
Positive Regulation Of Signal Transduction
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorylation
Immune Response-regulating Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of T Cell Activation
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Apoptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Actin Filament Bundle Assembly
Regulation Of Phosphorus Metabolic Process
Regulation Of Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Intracellular Transport
Positive Regulation Of Transferase Activity
Cellular Response To Chromate
Organelle Transport Along Microtubule
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell Death
Protein Complex Assembly
Regulation Of Lipid Kinase Activity
Cell Cycle Process
Fc Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Wnt Signaling Pathway
Positive Regulation Of DNA Replication
Cellular Macromolecular Complex Assembly
Regulation Of Signaling
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Actin Filament Organization
Positive Regulation Of Neuron Death
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Membrane Potential
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Hair Follicle Cell Proliferation
Suppression By Virus Of Host Apoptotic Process
T Cell Costimulation
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
MRNA Metabolic Process
RRNA Processing
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear MRNA Surveillance
DNA Deamination
RNA Surveillance
NcRNA Metabolic Process
RNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Cellular Macromolecule Catabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Metabolic Process
Histone MRNA Catabolic Process
RRNA Catabolic Process
DNA Modification
Establishment Of Localization In Cell
Histone MRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Immune System Process
Cellular Localization
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Nucleocytoplasmic Transport
Nuclear Transport
Regulation Of Growth
MRNA Export From Nucleus
Platelet Degranulation
Smooth Muscle Hyperplasia
Synaptic Growth At Neuromuscular Junction
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Complement Activation, Lectin Pathway
Tagcloud
?
10a
200c
30a
30c
arhgap5
cd36
cdh2
cdk5r1
chips
cyp27b1
figure
gemcitabine
gna13
gp5
hist1h2bf
hlf
igsf3
ikbkb
il32
intriguing
mirs
nrp2
oxidoreductase
putatively
rab23
rap2a
slc11a1
sod3
tp53i3
Tagcloud (Difference)
?
10a
200c
30a
30c
arhgap5
cd36
cdh2
cdk5r1
chips
cyp27b1
figure
gemcitabine
gna13
gp5
hist1h2bf
hlf
igsf3
ikbkb
il32
intriguing
mirs
nrp2
oxidoreductase
putatively
rab23
rap2a
slc11a1
sod3
tp53i3
Tagcloud (Intersection)
?