CRB3 and PARD6A

Number of citations of the paper that reports this interaction (PubMedID 14718572)
41

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CRB3	PARD6A
Description		crumbs cell polarity complex component 3	par-6 family cell polarity regulator alpha
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GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6	27 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		92359	50855
HPRD ID		16749	06316
Ensembl ID		ENSG00000130545	ENSG00000102981
Uniprot IDs		Q9BUF7	Q9NPB6
PDB IDs		5I7Z	1WMH
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol
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