CRB3 and UBIAD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRB3	UBIAD1
Description		crumbs cell polarity complex component 3	UbiA prenyltransferase domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Golgi Membrane Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane Organelle Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Prenyltransferase Activity Protein Binding Antioxidant Activity Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups
	Biological Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly	Ubiquinone Biosynthetic Process Menaquinone Metabolic Process Menaquinone Biosynthetic Process Vitamin K Biosynthetic Process Vitamin K Metabolic Process Cellular Oxidant Detoxification
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Metabolism of vitamin K
Drugs
Diseases			Schnyder corneal dystrophy (SCD); Schnyder crystalline corneal dystrophy (SCCD); Crystalline stromal dystrophy; Schnyder crystalline dystrophy sine crystals
GWAS			Beard thickness ( 26926045) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Intraocular pressure ( 29785010) Weight ( 28552196)
Interacting Genes		28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6	43 interacting genes: AHNAK2 AQP6 ASGR2 BIK CD33 CD53 CD79A CLDN7 CPLX4 CRB3 CREB3L1 CYB5R3 EBP ELOVL4 ERGIC3 EVI2A EVI2B FAM209A FCER1G FKBP7 FNDC9 GPR152 HIBADH KCNJ6 LHFPL5 MGST3 MRM3 NCAPH2 PHACTR3 PIGP REEP4 RETREG3 SAR1A SCN3B SLC10A1 SLC10A6 SLC7A14 SYT1 TIMMDC1 TMEFF2 TMEM139 TMEM14B VEGFA
Entrez ID		92359	29914
HPRD ID		16749	15487
Ensembl ID		ENSG00000130545	ENSG00000120942
Uniprot IDs		Q9BUF7	Q9Y5Z9
PDB IDs		5I7Z
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity	Membrane Protein Binding Bile Acid:sodium Symporter Activity
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