CRB3 and TMEM222

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRB3	TMEM222
Description		crumbs cell polarity complex component 3	transmembrane protein 222
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Membrane Dendrite Cell Projection
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 31219225)
Interacting Genes		28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6	40 interacting genes: ABHD16A AQP6 BIK BSCL2 CD79A CLDN5 CLRN1 COMT CRB3 CREB3 CREB3L1 EBP ELOVL4 ERG28 ERGIC3 EVI2B FAM174A FAM209A HIBADH HSD17B13 KIR2DL3 LMNA LRRC59 NCR3LG1 PEX12 PRSS23 PTGES RETREG3 RNASEK RUNX1 SLC10A1 SLC10A2 SLC10A6 SSMEM1 STX1A TMEM14B TMEM35A TMPRSS2 TMX2 ZDHHC15
Entrez ID		92359	84065
HPRD ID		16749	13167
Ensembl ID		ENSG00000130545	ENSG00000186501
Uniprot IDs		Q9BUF7	Q9H0R3
PDB IDs		5I7Z
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity	Membrane Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Membrane Bile Acid And Bile Salt Transport Endoplasmic Reticulum Protein Binding Positive Regulation Of Granulocyte Differentiation
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