CRB3 and SERP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRB3	SERP1
Description		crumbs cell polarity complex component 3	stress associated endoplasmic reticulum protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS			Academic attainment (English) ( 33594131)
Interacting Genes		28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6	56 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9
Entrez ID		92359	27230
HPRD ID		16749	18037
Ensembl ID		ENSG00000130545	ENSG00000120742
Uniprot IDs		Q9BUF7	Q9Y6X1
PDB IDs		5I7Z
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity	Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity
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