EVI5 and CCDC185

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		EVI5	CCDC185
Name		ecotropic viral integration site 5	coiled-coil domain containing 185
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton	None
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Retrograde Transport, Endosome To Golgi Positive Regulation Of GTPase Activity Cell Division Regulation Of Cilium Assembly	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Apolipoprotein B levels ( 32203549 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Body fat percentage and LDL-C (pairwise) ( 33619380 ) Cholesterol, total ( 25961943 24097068 20686565 ) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262 ) LDL cholesterol ( 25961943 30275531 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 33339817 32154731 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 19525955 31604244 21833088 24076602 27386562 ) Systemic lupus erythematosus ( 28714469 ) Total cholesterol levels ( 30275531 28334899 33339817 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: ARL4A AURKB BIRC5 CCDC185 CEP19 CSNK1D ELOA FAM161A FBXO5 IMP3 INCENP LENG1 LMO1 MB21D2 MCRS1 MORF4L2 PRPF31 STX3 TCEANC TNFAIP8L1 ZNF446	49 interacting genes: AMOTL2 BACH2 CADPS CALCOCO2 CBY2 CCDC136 CCDC85B CDR2L CEP44 CEP57 EVI5 EVI5L FAM161A GEMIN4 GOLGA2 GOLGA6L9 GRIPAP1 HSF2BP IKZF1 ISY1-RAB43 KRT15 KRT27 KRT35 KRT40 KRTAP10-7 KRTAP4-12 KXD1 LURAP1 MAGEA11 MAGEA2 MAGEA2B MAGEA6 MCC MDFI MID2 MKRN3 MTUS2 NAP1L2 NUTM1 PDLIM7 PKNOX2 PPP1R12C SPRED1 SPTA1 TBC1D1 TRAF1 TRIM27 VPS52 ZRANB1
Entrez ID		7813	164127
HPRD ID		04249	08761
Ensembl ID		ENSG00000067208	ENSG00000178395
Uniprot IDs		A0A804HIC4 A0A9L9PXE3 A0A9L9PXL1 A0A9L9PYE8 O60447 Q59FE7	Q8N715
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome Passenger Complex Spindle Assembly Spindle Microtubule Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Sister Chromatid Separation Spindle Organization Positive Regulation Of Cell Cycle Checkpoint Regulation Of Chromosome Separation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nucleoplasm Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Positive Regulation Of Chromosome Separation Regulation Of Chromosome Organization Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Organelle Assembly Membraneless Organelle Assembly Regulation Of Chromosome Segregation Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore Mitotic Cytokinesis Chromocenter Negative Regulation Of Chromosome Organization Regulation Of Cytokinesis Positive Regulation Of Cell Division Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Cytoskeleton Positive Regulation Of Cell Cycle Process Microtubule-based Process Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Cell Cycle Mitotic Cell Cycle	Keratin Filament Cytoskeleton Intermediate Filament Structural Constituent Of Skin Epidermis Negative Regulation Of Protein Acetylation Intermediate Filament Organization Microtubule Binding Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytosol PML Body Negative Regulation Of Protein Sumoylation Histone Deacetylase Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Viral Transcription Identical Protein Binding Suppression Of Viral Release By Host