EVI5 and FBXO5

Number of citations of the paper that reports this interaction (PMID 16439210)
25

Data Source:
HPRD (in vivo)

		EVI5	FBXO5
Gene Name		ecotropic viral integration site 5	F-box protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function	Rab GTPase Activator Activity Protein Binding Rab GTPase Binding	Protein Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Cell Cycle Multicellular Organismal Development Cell Proliferation Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Cell Division Regulation Of Cilium Assembly	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Spindle Assembly Involved In Female Meiosis I Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Vesicle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Meiotic Nuclear Division Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Inhibition Of APC-Cdc20 Complex Activity
Pathways			E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Mitotic G1-G1/S phases M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Multiple sclerosis ( 19525955 21833088)	Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: AURKB BIRC5 FBXO5 INCENP	16 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC CDC16 CDC20 CDC23 CDC27 CDK1 EVI5 FZR1 SKP1 TPM3
Entrez ID		7813	26271
HPRD ID		04249	09348
Ensembl ID		ENSG00000067208	ENSG00000112029
Uniprot IDs		F5H4R0 O60447 Q59FE7	Q9UKT4
PDB IDs			2M6N
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Cell Division Spindle Assembly Cytokinesis Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Mitotic Spindle Assembly Regulation Of Cell Division Cell Cycle Spindle Checkpoint Mitotic Spindle Organization Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Microtubule-based Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Inhibition Of APC-Cdc20 Complex Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Protein Complex Assembly Regulation Of Type B Pancreatic Cell Proliferation Organelle Organization Cytoskeleton Organization Histone H3-S28 Phosphorylation Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint Positive Regulation Of Exit From Mitosis Spindle Stabilization Negative Regulation Of APC-Cdc20 Complex Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Abscission Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Spindle Assembly Involved In Female Meiosis I Mitotic Spindle Elongation Spindle Assembly Involved In Meiosis Cellular Protein Complex Assembly Negative Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Spindle Assembly Checkpoint Positive Regulation Of Proteolysis Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Cell Cycle Checkpoint Regulation Of Chromosome Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Checkpoint Protein Catabolic Process Protein Polyubiquitination Cell Division Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Protein Catabolic Process
Tagcloud ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular
Tagcloud (Difference) ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular
Tagcloud (Intersection) ?