EVI5 and AURKB

Number of citations of the paper that reports this interaction (PubMedID 16764853)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EVI5	AURKB
Description		ecotropic viral integration site 5	aurora kinase B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity
	Biological Process	Retrograde Transport, Endosome To Golgi Positive Regulation Of GTPase Activity Cell Division Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein B levels ( 32203549) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat percentage and LDL-C (pairwise) ( 33619380) Cholesterol, total ( 25961943 24097068 20686565) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) LDL cholesterol ( 25961943 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 19525955 31604244 21833088 24076602 27386562) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 30275531 28334899 33339817)	Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		21 interacting genes: ARL4A AURKB BIRC5 CCDC185 CEP19 CSNK1D ELOA FAM161A FBXO5 IMP3 INCENP LENG1 LMO1 MB21D2 MCRS1 MORF4L2 PRPF31 STX3 TCEANC TNFAIP8L1 ZNF446	57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37
Entrez ID		7813	9212
HPRD ID		04249	05397
Ensembl ID		ENSG00000067208	ENSG00000178999
Uniprot IDs		A0A804HIC4 A0A9L9PXE3 A0A9L9PXL1 A0A9L9PYE8 O60447 Q59FE7	Q96GD4
PDB IDs			4AF3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome Passenger Complex Spindle Assembly Spindle Microtubule Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Sister Chromatid Separation Spindle Organization Positive Regulation Of Cell Cycle Checkpoint Regulation Of Chromosome Separation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nucleoplasm Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Positive Regulation Of Chromosome Separation Regulation Of Chromosome Organization Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Organelle Assembly Membraneless Organelle Assembly Regulation Of Chromosome Segregation Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore Mitotic Cytokinesis Chromocenter Negative Regulation Of Chromosome Organization Regulation Of Cytokinesis Positive Regulation Of Cell Division Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Cytoskeleton Positive Regulation Of Cell Cycle Process Microtubule-based Process Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Cell Cycle Mitotic Cell Cycle	Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis
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