EVI5 and BIRC5

Number of citations of the paper that reports this interaction (PMID 16764853)
5

Data Source:
BioGRID (pull down)

		EVI5	BIRC5
Gene Name		ecotropic viral integration site 5	baculoviral IAP repeat containing 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Intracellular Membrane-bounded Organelle	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytoplasm Centriole Spindle Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex
	Molecular Function	Rab GTPase Activator Activity Protein Binding Rab GTPase Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Ran GTPase Binding Tubulin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cofactor Binding Cobalt Ion Binding Chaperone Binding
	Biological Process	Cell Cycle Multicellular Organismal Development Cell Proliferation Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Cell Division Regulation Of Cilium Assembly	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Transcription, DNA-templated Protein Phosphorylation Chromosome Segregation Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Protein Ubiquitination Protein Complex Localization Positive Regulation Of Exit From Mitosis Spindle Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Chromosome Localization Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Multiple sclerosis ( 19525955 21833088)	Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		4 interactors: AURKB BIRC5 FBXO5 INCENP	22 interactors: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CDCA8 CDK1 CDK4 DIABLO EVI5 HIST2H3C HIST3H3 HSP90AA1 INCENP KCNJ6 RASA1 XIAP XPO1
Entrez ID		7813	332
HPRD ID		04249	04520
Ensembl ID		ENSG00000067208	ENSG00000089685
Uniprot IDs		F5H4R0 O60447 Q59FE7	H3BLT4 O15392
PDB IDs			1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Cell Division Spindle Assembly Cytokinesis Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Mitotic Spindle Assembly Regulation Of Cell Division Cell Cycle Spindle Checkpoint Mitotic Spindle Organization Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Microtubule-based Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Inhibition Of APC-Cdc20 Complex Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Protein Complex Assembly Regulation Of Type B Pancreatic Cell Proliferation Organelle Organization Cytoskeleton Organization Histone H3-S28 Phosphorylation Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint Positive Regulation Of Exit From Mitosis Spindle Stabilization Negative Regulation Of APC-Cdc20 Complex Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Abscission Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Spindle Assembly Involved In Female Meiosis I Mitotic Spindle Elongation Spindle Assembly Involved In Meiosis Cellular Protein Complex Assembly Negative Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Cell Division Mitotic Cell Cycle Regulation Of Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitotic Nuclear Division Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Histone Phosphorylation Positive Regulation Of Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Cytokinesis Histone-serine Phosphorylation Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Zymogen Activation Cytokinesis Peptidyl-serine Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cell Cycle Process Positive Regulation Of Cysteine-type Endopeptidase Activity Spindle Stabilization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Mitotic Spindle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity
Tagcloud ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?