EVI5 and INCENP

Number of citations of the paper that reports this interaction (PMID 16764853)
5

Data Source:
BioGRID (pull down)

		EVI5	INCENP
Gene Name		ecotropic viral integration site 5	inner centromere protein antigens 135/155kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex
	Molecular Function	Rab GTPase Activator Activity Protein Binding Rab GTPase Binding	Protein Binding
	Biological Process	Cell Cycle Multicellular Organismal Development Cell Proliferation Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Cell Division Regulation Of Cilium Assembly	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Multiple sclerosis ( 19525955 21833088)	Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		4 interactors: AURKB BIRC5 FBXO5 INCENP	10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C
Entrez ID		7813	3619
HPRD ID		04249	05103
Ensembl ID		ENSG00000067208	ENSG00000149503
Uniprot IDs		F5H4R0 O60447 Q59FE7	Q9NQS7
PDB IDs			2QFA 4AF3
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Cell Division Spindle Assembly Cytokinesis Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Mitotic Spindle Assembly Regulation Of Cell Division Cell Cycle Spindle Checkpoint Mitotic Spindle Organization Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Microtubule-based Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Inhibition Of APC-Cdc20 Complex Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Protein Complex Assembly Regulation Of Type B Pancreatic Cell Proliferation Organelle Organization Cytoskeleton Organization Histone H3-S28 Phosphorylation Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint Positive Regulation Of Exit From Mitosis Spindle Stabilization Negative Regulation Of APC-Cdc20 Complex Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Abscission Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Spindle Assembly Involved In Female Meiosis I Mitotic Spindle Elongation Spindle Assembly Involved In Meiosis Cellular Protein Complex Assembly Negative Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process See more	Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding See more
Tagcloud ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?