PTPA and GRIN3A

Number of citations of the paper that reports this interaction (PubMedID 15194871)
0

Data Source:
BioGRID (two hybrid)

		PTPA	GRIN3A
Description		protein phosphatase 2 phosphatase activator	glutamate ionotropic receptor NMDA type subunit 3A
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Monoatomic Ion Channel Complex Neuron Projection Neuronal Cell Body Organelle Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Neurotransmitter Receptor Complex Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Transmitter-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Serine Binding Glycine-gated Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process	Monoatomic Ion Transport Calcium Ion Transport Dendrite Development Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Regulation Of Synaptic Plasticity Rhythmic Process Neuron Development Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Negative Regulation Of Dendritic Spine Development Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways			Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Profenamine Secobarbital Dextromethorphan Dextropropoxyphene Acamprosate Procaine Donepezil Guaifenesin Ethanol Amantadine Memantine Halothane Orphenadrine Phenobarbital Ketamine Aripiprazole Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT	6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA
Entrez ID		5524	116443
HPRD ID		02858	09443
Ensembl ID		ENSG00000119383	ENSG00000198785
Uniprot IDs		F6WIT2 Q15257	Q8TCU5
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	8USW 8USX 8UUE
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor	Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential NMDA Glutamate Receptor Activity Regulation Of Neuronal Synaptic Plasticity NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Excitatory Chemical Synaptic Transmission Postsynaptic Density Membrane Regulation Of Nervous System Process Positive Regulation Of Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Postsynaptic Membrane Postsynaptic Density Learning Or Memory Excitatory Postsynaptic Potential Cognition Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Neuron Projection Trans-synaptic Signaling Glutamate Binding Synaptic Signaling Amyloid-beta Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Postsynaptic Membrane Potential Glycine Binding Regulation Of Membrane Potential Response To Ethanol Synaptic Vesicle Modulation Of Chemical Synaptic Transmission Protein Heterotetramerization Dendritic Spine Learning Regulation Of System Process Monoatomic Ion Channel Activity Calcium-mediated Signaling Cell-cell Signaling Signaling Calcium Ion Transmembrane Transport Cell Communication Regulation Of Transport Protein Heterooligomerization Excitatory Synapse Brain Development
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