PTPA and F3

Number of citations of the paper that reports this interaction (PubMedID 27599717)
0

Data Source:
BioGRID (enzymatic study)

		PTPA	F3
Description		protein phosphatase 2 phosphatase activator	coagulation factor III, tissue factor
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Serine-type Peptidase Complex
	Molecular Function	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding	Protease Binding Serine-type Endopeptidase Activity Cytokine Receptor Activity Protein Binding Phospholipid Binding
	Biological Process	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Response To Stress Blood Coagulation Hemostasis Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription
Drugs			IIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human Tisotumab vedotin
Diseases
GWAS			Blood protein levels in cardiovascular risk ( 28369058) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) End-stage coagulation ( 23381943) Smoking status (heavy vs never) ( 26423011) Type 2 diabetes ( 22238593)
Interacting Genes		32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT	8 interacting genes: F10 F7 FANCB FLNA HPCAL4 MDM2 PLG PTPA
Entrez ID		5524	2152
HPRD ID		02858	00603
Ensembl ID		ENSG00000119383	ENSG00000117525
Uniprot IDs		F6WIT2 Q15257	P13726
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA 5W06 6R2W 6Z9W 8CN9 8QOD 8QQ6 8UUD
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor	Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Cell Migration Regulation Of Cell Motility Serine-type Endopeptidase Activity Regulation Of Locomotion Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Protein Domain Specific Binding Regulation Of Body Fluid Levels Protein Maturation Positive Regulation Of Wound Healing Response To Astaxanthin Response To Estrogen Regulation Of Blood Coagulation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Nucleocytoplasmic Transport Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Hemostasis Response To Vitamin Signaling Receptor Binding Endopeptidase Activity Positive Regulation Of TOR Signaling Tissue Remodeling Positive Regulation Of Intracellular Protein Transport Mitotic Spindle Organization Golgi Lumen Serine-type Peptidase Complex Peptidase Activity Response To Thyrotropin-releasing Hormone Kinase Binding Regulation Of Cell Communication Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Regulation Of Signaling Proteolysis Regulation Of Nucleocytoplasmic Transport Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
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