PTPA and DTD1

Number of citations of the paper that reports this interaction (PubMedID 25258324)
47

Data Source:
BioGRID (enzymatic study)

		PTPA	DTD1
Description		protein phosphatase 2 phosphatase activator	D-aminoacyl-tRNA deacylase 1
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding	TRNA Binding Aminoacyl-tRNA Deacylase Activity DNA Binding RNA Binding Hydrolase Activity Metal Ion Binding D-aminoacyl-tRNA Deacylase Activity D-tyrosyl-tRNA(Tyr) Deacylase Activity Gly-tRNA(Ala) Deacylase Activity
	Biological Process	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process	DNA Replication TRNA Metabolic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30679032) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) C-reactive protein (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT	4 interacting genes: CDC7 CSNK2A1 NR3C1 PTPA
Entrez ID		5524	92675
HPRD ID		02858	13631
Ensembl ID		ENSG00000119383	ENSG00000125821
Uniprot IDs		F6WIT2 Q15257	A0A2R8Y6X2 Q8TEA8
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	2OKV
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor	Hsp90 Protein Binding Recombinational Repair Double-strand Break Repair Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Double-strand Break Repair Via Homologous Recombination DNA Recombination Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Nuclear Glucocorticoid Receptor Activity Protein Tyrosine Phosphatase Activator Activity Aggrephagy Nucleotide Binding ATP Binding Regulation Of Programmed Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Apoptotic Process Protein Serine Kinase Activity Nucleoplasm Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Serine/threonine Kinase Activity Regulation Of Glucocorticoid Biosynthetic Process Neuroinflammatory Response Response To Cortisol Regulation Of Glucocorticoid Metabolic Process Mammary Gland Duct Morphogenesis Microglia Differentiation Estrogen Response Element Binding Steroid Hormone Binding Maternal Behavior Regulation Of Steroid Hormone Biosynthetic Process Parental Behavior Glucocorticoid Metabolic Process Phosphatase Activator Activity Protein Phosphatase Type 2A Complex ATPase Complex Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of DNA-templated DNA Replication MRNA Methylguanosine-cap Decapping Regulation Of Cell Cycle Phase Transition Cell Division Core Promoter Sequence-specific DNA Binding Regulation Of DNA Metabolic Process Sin3-type Complex Protein Kinase Activity DNA Repair
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