PTPA and NIF3L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTPA	NIF3L1
Description		protein phosphatase 2 phosphatase activator	NGG1 interacting factor 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS			Triptolide cytotoxicity ( 26121980)
Interacting Genes		32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		5524	60491
HPRD ID		02858	10424
Ensembl ID		ENSG00000119383	ENSG00000196290
Uniprot IDs		F6WIT2 Q15257	Q9GZT8
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor	Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination
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