PPP2R4 and CCNG2

Number of citations of the paper that reports this interaction (PMID 11956189)
46

Data Source:
HPRD (in vitro)

		PPP2R4	CCNG2
Gene Name		protein phosphatase 2A activator, regulatory subunit 4	cyclin G2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Type 2A Regulator Activity ATPase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	Cell Cycle Checkpoint Mitotic Nuclear Division Cell Division Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS		Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Protein-Protein Interactions		19 interactors: AKT1 AMOT APP AURKB BCL2 CCNG1 CCNG2 CSNK2A1 CYLD EIF4EBP1 H2AFX HDAC4 MAPT MID1 PIM1 PPP2R3A PRKCB RACGAP1 SRC	5 interactors: EFHC2 FAM208B NRIP2 PPP2CA PPP2R4
Entrez ID		5524	901
HPRD ID		02858	04438
Ensembl ID		ENSG00000119383	ENSG00000138764
Uniprot IDs		B4DZF8 Q15257	Q16589 Q6FGC6
PDB IDs		2G62 2HV6 2HV7 2IXM
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Regulation Of Cellular Component Organization Organelle Organization Multicellular Organismal Development Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Microtubule-based Process Apoptotic Process Developmental Process Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Binding Response To Stress Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Nervous System Development Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Cell Growth Negative Regulation Of Mitochondrial Depolarization Regulation Of Growth Negative Regulation Of Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process	Mitotic Spindle Organization In Nucleus Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Mitotic Nuclear Envelope Reassembly Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Phosphoprotein Phosphatase Activity Mitotic Cell Cycle Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of JAK-STAT Cascade Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphatase Activity Inactivation Of MAPK Activity Negative Regulation Of Protein Metabolic Process Protein Trimerization Negative Regulation Of Stem Cell Differentiation Positive Regulation Of Protein Modification Process Regulation Of Phosphoprotein Phosphatase Activity Mitotic Spindle Organization Cell Cycle Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Dephosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Phosphatase Activity Positive Regulation Of Protein Metabolic Process Nuclear Envelope Organization Negative Regulation Of Dephosphorylation Protein Peptidyl-prolyl Isomerization Cell Cycle Negative Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of JAK-STAT Cascade Ceramide Metabolic Process Positive Regulation Of Catalytic Activity Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Cell Morphogenesis Involved In Differentiation Protein Metabolic Process Regulation Of Phosphatase Activity
Tagcloud ?		al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate	95d altered arrest atpase c3orf1 carcinoma col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably nupr1 preliminary pten remarkably timmdc1 timp3 translocase upregulated viable
Tagcloud (Difference) ?		al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate	95d altered arrest atpase c3orf1 carcinoma col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably nupr1 preliminary pten remarkably timmdc1 timp3 translocase upregulated viable
Tagcloud (Intersection) ?