PPP2R4 and CYLD

Number of citations of the paper that reports this interaction (PMID 20593489)
5

Data Source:
BioGRID (pull down)

		PPP2R4	CYLD
Gene Name		protein phosphatase 2A activator, regulatory subunit 4	cylindromatosis (turban tumor syndrome)
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Vesicular Exosome	Nucleoplasm Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Type 2A Regulator Activity ATPase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Protein Phosphatase 2A Binding	Structural Constituent Of Ribosome Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	Cytoplasmic Translation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Innate Immune Response Negative Regulation Of T Cell Differentiation Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Cilium Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS		Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)	Bone mineral density ( 22504420) Crohn's disease ( 22412388) Leprosy ( 22019778)
Protein-Protein Interactions		19 interactors: AKT1 AMOT APP AURKB BCL2 CCNG1 CCNG2 CSNK2A1 CYLD EIF4EBP1 H2AFX HDAC4 MAPT MID1 PIM1 PPP2R3A PRKCB RACGAP1 SRC	15 interactors: AKT1 AURKB DDX58 HDAC6 IKBKG ITCH MAPRE1 OPTN PPP2R4 TRAF2 TRAF6 TRAF7 TRAIP TUBA1A UBE2S
Entrez ID		5524	1540
HPRD ID		02858	05427
Ensembl ID		ENSG00000119383	ENSG00000083799
Uniprot IDs		B4DZF8 Q15257	Q9NQC7
PDB IDs		2G62 2HV6 2HV7 2IXM	1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Regulation Of Cellular Component Organization Organelle Organization Multicellular Organismal Development Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Microtubule-based Process Apoptotic Process Developmental Process Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Binding Response To Stress Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Nervous System Development Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Cell Growth Negative Regulation Of Mitochondrial Depolarization Regulation Of Growth Negative Regulation Of Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Polyubiquitination Cell Death Death Regulation Of Cell Death Positive Regulation Of Innate Immune Response Mitotic Cell Cycle Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Catabolic Process Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death NIK/NF-kappaB Signaling Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of JNK Cascade Cellular Protein Modification Process Protein K29-linked Ubiquitination Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Innate Immune Response Intracellular Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate	181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate
Tagcloud (Difference) ?		al355149 algorithm annotation cisplatin dataset deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic	181b adjacent assays blot coding colony corroboration downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr
Tagcloud (Intersection) ?		array deregulated validate