PRPF4 and WBP4

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		PRPF4	WBP4
Gene Name		pre-mRNA processing factor 4	WW domain binding protein 4
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP	Nucleoplasm Spliceosomal Complex Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding U6 SnRNA Binding U4 SnRNA Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression	MRNA Cis Splicing, Via Spliceosome
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Crohn's disease ( 23266558)
Protein-Protein Interactions		12 interactors: APP ATP5J2 CLK1 GPKOW NHP2L1 PPIH PRPF3 PRPF31 SRSF1 TGFBR1 U2AF1 WBP4	44 interactors: BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DIAPH1 DNM2 EFTUD2 EWSR1 FUS HLTF HNRNPK HNRNPU HTATSF1 KHDRBS1 NONO PABPC1 PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B3 SF3B4 SFPQ SNRNP70 SNRPA SNRPB TCERG1 WAS WBP11 WIPF1 XRCC6 ZNF207
Entrez ID		9128	11193
HPRD ID		08479	16086
Ensembl ID		ENSG00000136875	ENSG00000120688
Uniprot IDs		O43172 Q5T1M7	B7Z4M2 O75554
PDB IDs		1MZW	2DK1 2JXW
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Splicing MRNA 3'-end Processing Spliceosomal Tri-snRNP Complex Assembly Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Assembly Cellular Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Peptidyl-threonine Phosphorylation MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of RNA Splicing Collateral Sprouting In Absence Of Injury Cellular Component Assembly Peptidyl-serine Phosphorylation Nuclear Export MRNA Transport RNA Transport Regulation Of Protein Binding Collateral Sprouting Axon Midline Choice Point Recognition MRNA 5'-splice Site Recognition RNA Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Macromolecular Complex Assembly Parathyroid Gland Development Neuron Remodeling Intracellular Transport Endothelial Cell Activation	MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly MRNA 3'-splice Site Recognition Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Cellular Component Assembly MRNA Splice Site Selection Cellular Process Metabolic Process MRNA 3'-end Processing Transcription, DNA-templated RNA Biosynthetic Process RNA 3'-end Processing Spliceosomal SnRNP Assembly Posttranscriptional Regulation Of Gene Expression Attachment Of Spindle Microtubules To Kinetochore Rhythmic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Translational Initiation Macromolecule Biosynthetic Process Positive Regulation Of Translation Actin Polymerization Or Depolymerization Negative Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Positive Regulation Of Gene Expression MRNA Polyadenylation Cellular Response To Osmotic Stress
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