PRPF4 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PRPF4	WBP4
Description		pre-mRNA splicing tri-snRNP complex factor PRPF4	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Protein Binding U6 SnRNA Binding U4 SnRNA Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		White matter growth ( 29682794)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		10 interacting genes: APP ATP5MF CEBPA CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		9128	11193
HPRD ID		08479	16086
Ensembl ID		ENSG00000136875	ENSG00000120688
Uniprot IDs		O43172 Q5T1M7	O75554
PDB IDs		1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing RS Domain Binding MRNA Metabolic Process RNA Metabolic Process RNA Processing Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Gland Development Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Acetylcholine Receptor Activator Activity Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Nucleus Regulation Of Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex Protein Localization To P-body Catalytic Step 2 Spliceosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Liver Development Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex U4/U6 SnRNP Notch Signaling Pathway Response To Norepinephrine	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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