PRPF4 and U2AF1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		PRPF4	U2AF1
Description		pre-mRNA splicing tri-snRNP complex factor PRPF4	U2 small nuclear RNA auxiliary factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex
	Molecular Function	Protein Binding U6 SnRNA Binding U4 SnRNA Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding RS Domain Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		White matter growth ( 29682794)	Blood and toenail selenium levels ( 25343990)
Interacting Genes		10 interacting genes: APP ATP5MF CEBPA CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4	58 interacting genes: ALG13 AP1B1 AP2B1 CARNMT1 CHERP CIRSR CLK2 CPEB2 DHX38 EFHC2 EPB41 FILNC1 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRPK2 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA VPS26C WEE2-AS1 ZCCHC10 ZNF417 ZRANB2 ZRSR2
Entrez ID		9128	7307
HPRD ID		08479	01871
Ensembl ID		ENSG00000136875	ENSG00000160201
Uniprot IDs		O43172 Q5T1M7	Q01081 Q7Z780
PDB IDs		1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	1JMT
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing RS Domain Binding MRNA Metabolic Process RNA Metabolic Process RNA Processing Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Gland Development Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Acetylcholine Receptor Activator Activity Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Nucleus Regulation Of Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex Protein Localization To P-body Catalytic Step 2 Spliceosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Liver Development Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex U4/U6 SnRNP Notch Signaling Pathway Response To Norepinephrine	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Nucleic Acid Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Nuclear Speck Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Nucleus Nucleoplasm Protein-RNA Complex Assembly Macromolecule Metabolic Process MRNA Binding U2-type Precatalytic Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process U12-type Spliceosomal Complex Negative Regulation Of RNA Splicing U2-type Spliceosomal Complex Positive Regulation Of RNA Splicing Precatalytic Spliceosome U1 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Negative Regulation Of RNA Metabolic Process Protein-containing Complex Assembly U2-type Prespliceosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process U2 SnRNP Commitment Complex Positive Regulation Of Viral Genome Replication Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA Splice Site Recognition Regulation Of RNA Metabolic Process Protein-containing Complex Organization MRNA 5'-splice Site Recognition T Cell Differentiation In Thymus
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