WWOX and NUDT21

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		WWOX	NUDT21
Gene Name		WW domain containing oxidoreductase	nudix (nucleoside diphosphate linked moiety X)-type motif 21
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Centrosome MRNA Cleavage Factor Complex Paraspeckles
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Protein Dimerization Activity Cofactor Binding Coenzyme Binding	RNA Binding MRNA Binding Protein Binding Hydrolase Activity AU-rich Element Binding Protein Homodimerization Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	Osteoblast Differentiation Steroid Metabolic Process Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing Protein Tetramerization
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Cardiac structure and function ( 19584346) Metabolite levels (5-HIAA) ( 23319000) Obesity ( 21552555) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Radiation response ( 20923822) Reasoning ( 21107309) Response to amphetamines ( 22952603) Type 2 diabetes ( 22158537)
Protein-Protein Interactions		17 interactors: CPSF2 CPSF7 EZR FIP1L1 HNRNPK LATS1 MAPK8 NUDT21 SF3B3 SRC TCERG1 TNK2 TP53 TP73 UBB WDR33 WIPF2	51 interactors: A2M ATXN1 CARM1 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G EXOSC6 F13A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIAA1377 KIFAP3 MASP1 MYL6 NEDD4 NGEF NIF3L1 POLR2C PSMF1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 SEMA5B SF3B1 SHC1 SHFM1 SLC44A1 SNCAIP SNRNP70 SRPK1 TCERG1 TLE1 TRA2A TRIM27 WWOX ZBTB48
Entrez ID		51741	11051
HPRD ID		05501	05400
Ensembl ID		ENSG00000186153	ENSG00000167005
Uniprot IDs		Q9NZC7	O43809
PDB IDs		1WMV	2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Processing MRNA 3'-end Processing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Polyadenylation Protein Tetramerization RNA Metabolic Process RNA Polyadenylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Termination Of RNA Polymerase II Transcription Gene Expression RNA Splicing Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Phosphorylation DNA-templated Transcription, Termination DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Gene Expression Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process MRNA Cleavage Regulation Of Protein Phosphorylation	Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Process Cellular Metabolic Process Viral Process Protein K63-linked Ubiquitination RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Polyubiquitination Negative Regulation Of Complement Activation MRNA 3'-end Processing Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Immune System Process Developmental Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Regulation Of Dendrite Development Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Blood Coagulation Macromolecule Biosynthetic Process Hemostasis Protein Oligomerization MRNA Polyadenylation Anatomical Structure Development
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Intersection) ?