WWOX and TNK2

Number of citations of the paper that reports this interaction (PMID 16288044)
44

Data Source:
HPRD (in vivo)

		WWOX	TNK2
Gene Name		WW domain containing oxidoreductase	tyrosine kinase, non-receptor, 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Protein Dimerization Activity Cofactor Binding Coenzyme Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding
	Biological Process	Osteoblast Differentiation Steroid Metabolic Process Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs			Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS		Anorexia nervosa ( 23568457) Cardiac structure and function ( 19584346) Metabolite levels (5-HIAA) ( 23319000) Obesity ( 21552555) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Radiation response ( 20923822) Reasoning ( 21107309) Response to amphetamines ( 22952603) Type 2 diabetes ( 22158537)
Protein-Protein Interactions		17 interactors: CPSF2 CPSF7 EZR FIP1L1 HNRNPK LATS1 MAPK8 NUDT21 SF3B3 SRC TCERG1 TNK2 TP53 TP73 UBB WDR33 WIPF2	41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		51741	10188
HPRD ID		05501	06104
Ensembl ID		ENSG00000186153	ENSG00000061938
Uniprot IDs		Q9NZC7	B3KXJ4 C9J1X3 Q07912
PDB IDs		1WMV	1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Processing MRNA 3'-end Processing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Polyadenylation Protein Tetramerization RNA Metabolic Process RNA Polyadenylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Termination Of RNA Polymerase II Transcription Gene Expression RNA Splicing Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Phosphorylation DNA-templated Transcription, Termination DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Gene Expression Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process MRNA Cleavage Regulation Of Protein Phosphorylation	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?