WWOX and FIP1L1

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down, affinity chromatography technology)

		WWOX	FIP1L1
Gene Name		WW domain containing oxidoreductase	factor interacting with PAPOLA and CPSF1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Protein Dimerization Activity Cofactor Binding Coenzyme Binding	Poly(A) RNA Binding
	Biological Process	Osteoblast Differentiation Steroid Metabolic Process Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MRNA Processing
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Cardiac structure and function ( 19584346) Metabolite levels (5-HIAA) ( 23319000) Obesity ( 21552555) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Radiation response ( 20923822) Reasoning ( 21107309) Response to amphetamines ( 22952603) Type 2 diabetes ( 22158537)	DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		17 interactors: CPSF2 CPSF7 EZR FIP1L1 HNRNPK LATS1 MAPK8 NUDT21 SF3B3 SRC TCERG1 TNK2 TP53 TP73 UBB WDR33 WIPF2	11 interactors: APP CPSF4 CSNK2A1 GOLGA2 LIG4 NAA10 PRMT2 PRMT6 SGTA WWOX ZMYND19
Entrez ID		51741	81608
HPRD ID		05501	09646
Ensembl ID		ENSG00000186153	ENSG00000145216
Uniprot IDs		Q9NZC7	Q6UN15
PDB IDs		1WMV
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Processing MRNA 3'-end Processing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Polyadenylation Protein Tetramerization RNA Metabolic Process RNA Polyadenylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Termination Of RNA Polymerase II Transcription Gene Expression RNA Splicing Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Phosphorylation DNA-templated Transcription, Termination DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Gene Expression Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process MRNA Cleavage Regulation Of Protein Phosphorylation	Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Neuron Death DNA Ligation Involved In DNA Recombination Apoptotic Process Programmed Cell Death Regulation Of Mitotic Cell Cycle Chromosome Organization Developmental Cell Growth Cell Death Death Modification By Virus Of Host MRNA Processing Histone H3-R2 Methylation Synaptic Growth At Neuromuscular Junction N-terminal Peptidyl-glutamic Acid Acetylation N-terminal Peptidyl-serine Acetylation Regulation Of Cell Cycle Process Histone Methylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Binding Cell Growth Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Apoptotic Process Protein Methylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Pro-B Cell Differentiation Regulation Of Cell Death Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Negative Regulation Of Mitotic Cell Cycle Neuron Remodeling Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Regulation Of RNA Metabolic Process Steroid Metabolic Process Cell Development N-terminal Protein Amino Acid Acetylation Lymphoid Progenitor Cell Differentiation Regulation Of Binding
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone	adenopathy always atopic cd3 cd4 chart concern contrary corticosteroids cs dermatologic eosinophil eosinophilic french hes hypereosinophilia hypereosinophilic manifestations multicentric neurologic pdgfra phenotyping rearrangement rheumatologic scarce sparing superficial tcrgammadelta yr
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone	adenopathy always atopic cd3 cd4 chart concern contrary corticosteroids cs dermatologic eosinophil eosinophilic french hes hypereosinophilia hypereosinophilic manifestations multicentric neurologic pdgfra phenotyping rearrangement rheumatologic scarce sparing superficial tcrgammadelta yr
Tagcloud (Intersection) ?