WWOX

Description		WW domain containing oxidoreductase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Lysosome Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Apoptotic Process Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Eosinophil count ( 32888494) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) ghrelin levels ( 33852427) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Major depressive disorder x sex interaction ( 34099189) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Parkinson's disease progression (cognitive) ( 33958783) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Triglyceride levels ( 34074324) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		115 interacting genes: ABHD11 ABI2 ACAT2 ACTMAP ACY1 ADRA2C ANAPC11 ANXA11 APBB2 ATOSB C10orf55 C11orf87 CCDC24 CEACAM6 CLNK CNNM3 CPSF2 CPSF6 CPSF7 CREB5 CSNK2B CTAG1A CTAG1B CTDSP1 DAZAP2 DMRT3 ENKD1 ERBB4 EZR FAM222B FEM1A FIP1L1 FOXD4L1 FOXI1 FRS3 GCM2 GEM GLIS2 GNE HNRNPK HOXA1 HOXC8 HSPB2 HSPB2-C11orf52 HYAL2 IFIT2 INCA1 KLHDC7B KLHL38 KRT3 KRT34 KRT75 KRTAP11-1 LASP1 LATS1 LITAF LMO3 MAPK8 MED25 MKRN3 MYG1 MYOZ1 MYOZ2 NEDD9 NUDT21 OLIG3 OTX1 PATL1 PATZ1 PAX9 PBX4 PEF1 PITX2 PLAC8 PLEKHN1 PLSCR3 PSMB8 RAMAC RUSC1 SAXO1 SAXO4 SCAMP3 SEC23IP SF3B3 SH2D4A SHC3 SLC15A2 SMAD4 SMR3A SNRPC SPMIP9 SRC TCERG1 TCHP TEKT3 TFAP2C TFG TNK2 TP53 TP73 TRIM69 TSGA10IP UBB UFSP1 VENTX VEZF1 VPS37C WDR33 WIPF2 YPEL3 ZBTB32 ZIC1 ZNF135 ZNF414 ZNF581
Entrez ID		51741
HPRD ID		05501
Ensembl ID		ENSG00000186153
Uniprot IDs		A0A411HBC7 Q9NZC7
PDB IDs		1WMV
Enriched GO Terms of Interacting Partners?		MRNA Cleavage And Polyadenylation Specificity Factor Complex Protein Binding Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific MRNA Alternative Polyadenylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA 3'-end Processing MRNA Cleavage Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Chromatin DNA-binding Transcription Factor Activity MRNA Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Heterotetramerization Skeletal Muscle Fiber Adaptation RNA 3'-end Processing Positive Regulation Of Biosynthetic Process Anatomical Structure Morphogenesis Keratin Filament Histone Deacetylase Regulator Activity Protein Tetramerization Positive Regulation Of Protein Monoubiquitination FATZ Binding Regulation Of Primary Metabolic Process WW Domain Binding Axonemal A Tubule Inner Sheath DNA Binding Regulation Of Protein Monoubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Growth Protein Heterooligomerization Receptor Tyrosine Kinase Binding
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