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WWOX
Gene Name
WW domain containing oxidoreductase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
RNA Polymerase II Transcription Factor Complex
Molecular Function
RNA Polymerase II Transcription Coactivator Activity
Protein Binding
Oxidoreductase Activity
Enzyme Binding
Protein Dimerization Activity
Cofactor Binding
Coenzyme Binding
Biological Process
Osteoblast Differentiation
Steroid Metabolic Process
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Morphogenesis
Oxidation-reduction Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Nuclear signaling by ERBB4
Signaling by ERBB4
Drugs
Diseases
GWAS
Anorexia nervosa (
23568457
)
Cardiac structure and function (
19584346
)
Metabolite levels (5-HIAA) (
23319000
)
Obesity (
21552555
)
Pulmonary function (
21946350
)
Pulmonary function (interaction) (
23284291
)
Radiation response (
20923822
)
Reasoning (
21107309
)
Response to amphetamines (
22952603
)
Type 2 diabetes (
22158537
)
Protein-protein Interactions
17 interactors:
CPSF2
CPSF7
EZR
FIP1L1
HNRNPK
LATS1
MAPK8
NUDT21
SF3B3
SRC
TCERG1
TNK2
TP53
TP73
UBB
WDR33
WIPF2
Entrez ID
51741
HPRD ID
05501
Ensembl ID
ENSG00000186153
Uniprot IDs
Q9NZC7
PDB IDs
1WMV
Enriched GO Terms of Interacting Partners
?
MRNA Processing
MRNA Metabolic Process
Transcription From RNA Polymerase II Promoter
RNA Processing
MRNA 3'-end Processing
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA 3'-end Processing
MRNA Polyadenylation
Protein Tetramerization
RNA Metabolic Process
RNA Polyadenylation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Termination Of RNA Polymerase II Transcription
Gene Expression
RNA Splicing
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Phosphorylation
DNA-templated Transcription, Termination
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Modification Process
Fc Receptor Signaling Pathway
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
DNA Damage Response, Signal Transduction Resulting In Transcription
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Hypoxia
Mitotic DNA Integrity Checkpoint
Nucleobase-containing Compound Metabolic Process
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Gene Expression
Protein Complex Assembly
Positive Regulation Of Cell Death
Regulation Of Protein Metabolic Process
MRNA Cleavage
Regulation Of Protein Phosphorylation
Tagcloud
?
breaks
crosstalk
cyclopamine
ectopically
gbm
gli
glioblastoma
h2ax
hedgehog
impairing
ionizing
mtp53
multiforme
oxidoreductase
possessing
radiosensitivity
sensitize
shh
smo
smoothened
sonic
u373mg
u87mg
verify
warrants
wox1
wtp53
zerumbone