FXYD6 and TMEM35A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FXYD6	TMEM35A
Description		FXYD domain containing ion transport regulator 6	transmembrane protein 35A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity	Protein Binding Acetylcholine Receptor Regulator Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane	Chaperone-mediated Protein Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		67 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35E1 SLC35E3 SLC35H1 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119	32 interacting genes: ADIPOQ APP BET1 C16orf92 CMTM5 COX20 CTSA CXCL16 CYB5B EHHADH FXYD6 GIMAP1 GOSR2 LNPEP MGLL ORMDL1 RTP2 RUSF1 THBD TMEM106C TMEM120A TMEM14C TMEM201 TMEM222 TMEM229B TMEM243 TMEM42 TRIM55 TRIM63 VAMP1 VAMP3 VAPA
Entrez ID		53826	59353
HPRD ID		09456	06523
Ensembl ID		ENSG00000137726	ENSG00000126950
Uniprot IDs		Q9H0Q3	Q53FP2
PDB IDs		8D3U 8D3V 8D3W 8D3X 8D3Y	9H9E
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Antiporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Monoatomic Ion Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid	Membrane Membrane Fusion SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Sphingomyelin Biosynthetic Process SNARE Complex Assembly Cellular Localization Endoplasmic Reticulum Vesicle Organization Positive Regulation Of CAMP/PKA Signal Transduction Response To CAMP Endoplasmic Reticulum Membrane Sphingomyelin Metabolic Process
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