FXYD6 and PPP1CC

Number of citations of the paper that reports this interaction (PMID 23080069)
1

Data Source:
BioGRID (two hybrid)

		FXYD6	PPP1CC
Gene Name		FXYD domain containing ion transport regulator 6	protein phosphatase 1, catalytic subunit, gamma isozyme
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Molecular_function Ion Channel Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Biological_process Ion Transmembrane Transport Transmembrane Transport	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division
Pathways		Ion transport by P-type ATPases Ion channel transport	Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		13 interactors: BCAR1 C4BPA CCDC90B CREB3L1 GDF9 HAUS2 PPP1CC RBM48 SLC35E1 TLE1 TP53 TRIM27 UNC119	114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667
Entrez ID		53826	5501
HPRD ID		09456	08911
Ensembl ID		ENSG00000137726	ENSG00000186298
Uniprot IDs		Q9H0Q3	P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Cell Division Transforming Growth Factor Beta Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Adaptive Immune Response Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic Cell Cycle Response To Light Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Growth Signal Transduction Negative Regulation Of Clathrin-mediated Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Circadian Rhythm Cell Communication Cellular Response To Organic Substance Negative Regulation Of Macromitophagy Negative Regulation Of Interleukin-2 Secretion Regulation Of Opsonization Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth Oligodendrocyte Apoptotic Process Response To Radiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ER-nucleus Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Progesterone Secretion Notch Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Growth Cell Cycle	Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter
Tagcloud ?		afg3l2 anapc11 arf1 calgizzarin cki dci dph2l fb1 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		afg3l2 anapc11 arf1 calgizzarin cki dci dph2l fb1 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?