ASH2L and H3-4

Number of citations of the paper that reports this interaction (PubMedID 24793694)
56

Data Source:
BioGRID (pull down, enzymatic study)

		ASH2L	H3-4
Description		ASH2 like, histone lysine methyltransferase complex subunit	H3.4 histone, cluster member
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromatin Organization DNA Damage Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Hemopoiesis Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)
Interacting Genes		34 interacting genes: ACTC1 ACTN2 ANKRD1 BARD1 BRCA1 CCNC CEP76 COPS6 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 RBM39 SMAD9 SMURF1 SMURF2 TGFBR1 TTN UNC119 WWP1 ZSCAN1	195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516
Entrez ID		9070	8290
HPRD ID		05309	04156
Ensembl ID		ENSG00000129691	ENSG00000168148
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	Q16695
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 6W5I 6W5M 6W5N 7BRE 7MBM 7MBN 7UD5 7W67 7W6A 7W6I 7W6J 7W6L	2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Complex MLL1/2 Complex Epigenetic Regulation Of Gene Expression Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sarcomere Organization Regulation Of Gene Expression I-SMAD Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Actomyosin Structure Organization Protein-containing Complex Histone H3K4 Monomethyltransferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Nucleoplasm Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Regulation Of Primary Metabolic Process Titin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Condensed Nuclear Chromosome SMAD Binding Transcription Initiation-coupled Chromatin Remodeling Histone H3K4 Methyltransferase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Positive Regulation Of Gene Expression, Epigenetic Cardiac Muscle Tissue Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Muscle Tissue Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription M Band I Band Response To Muscle Stretch Positive Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process BRCA1-B Complex Transferase Activity R-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region
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