ASH2L and KMT2D

Number of citations of the paper that reports this interaction (PMID 16603732)
41

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vitro)

		ASH2L	KMT2D
Gene Name		ash2 (absent, small, or homeotic)-like (Drosophila)	lysine (K)-specific methyltransferase 2D
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex Set1C/COMPASS Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	DNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation	Oocyte Growth Chromatin Organization Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Histone H3-K4 Methylation
Pathways		Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer	Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		22 interactors: BARD1 BRCA1 CHD8 CTNNB1 DPY30 EP300 HCFC2 HIST1H3A HIST3H3 KMT2A KMT2D MEN1 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1	9 interactors: ASH2L CTNNB1 ESR1 HIST2H3C MEN1 POLR2A SMAD1 SMAD9 UBC
Entrez ID		9070	8085
HPRD ID		05309	03664
Ensembl ID		ENSG00000129691	ENSG00000167548
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	O14686 Q59FG6 Q6PIA1
PDB IDs		3RSN 3S32 3TOJ	3UVK 4ERQ
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Histone Modification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Biosynthetic Process Chromosome Organization Positive Regulation Of Histone Methylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Histone Methylation Regulation Of Histone Modification Positive Regulation Of Transcription, DNA-templated Regulation Of Histone Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Positive Regulation Of Gene Expression Protein Methylation Negative Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Nucleobase-containing Compound Metabolic Process Chromatin Modification Regulation Of Chromosome Organization Histone Modification Heterocycle Metabolic Process	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Nucleobase-containing Compound Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Osteoblast Fate Commitment Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Ossification Response To Organic Substance Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Kidney Epithelium Development
Tagcloud ?		acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad	aka belong bile circadian clock closest coactivator coactivators complexes disturbed fluctuation hepatic hepatology homolog impinges livers mechanistic metabolic methyltransferase mll3 mll4 named orphan pivotal regulators retinoid rhythmic transcriptome uncovered
Tagcloud (Difference) ?		acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad	aka belong bile circadian clock closest coactivator coactivators complexes disturbed fluctuation hepatic hepatology homolog impinges livers mechanistic metabolic mll3 mll4 named orphan pivotal regulators retinoid rhythmic transcriptome uncovered
Tagcloud (Intersection) ?		methyltransferase