ASH2L and WWP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ASH2L	WWP1
Description		ASH2 like, histone lysine methyltransferase complex subunit	WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization DNA Damage Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Hemopoiesis Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		34 interacting genes: ACTC1 ACTN2 ANKRD1 BARD1 BRCA1 CCNC CEP76 COPS6 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 RBM39 SMAD9 SMURF1 SMURF2 TGFBR1 TTN UNC119 WWP1 ZSCAN1	59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		9070	11059
HPRD ID		05309	03811
Ensembl ID		ENSG00000129691	ENSG00000123124
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	Q9H0M0
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 6W5I 6W5M 6W5N 7BRE 7MBM 7MBN 7UD5 7W67 7W6A 7W6I 7W6J 7W6L	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Complex MLL1/2 Complex Epigenetic Regulation Of Gene Expression Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sarcomere Organization Regulation Of Gene Expression I-SMAD Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Actomyosin Structure Organization Protein-containing Complex Histone H3K4 Monomethyltransferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Nucleoplasm Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Regulation Of Primary Metabolic Process Titin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Condensed Nuclear Chromosome SMAD Binding Transcription Initiation-coupled Chromatin Remodeling Histone H3K4 Methyltransferase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Positive Regulation Of Gene Expression, Epigenetic Cardiac Muscle Tissue Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Muscle Tissue Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription M Band I Band Response To Muscle Stretch Positive Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process BRCA1-B Complex Transferase Activity R-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process
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