MAPKAPK2 and DES

Number of citations of the paper that reports this interaction (PubMedID 15094067)
0

Data Source:
BioGRID (two hybrid)

		MAPKAPK2	DES
Description		MAPK activated protein kinase 2	desmin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Ciliary Basal Body Extracellular Exosome	Nucleus Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Fascia Adherens Intercalated Disc Membrane Z Disc Neuromuscular Junction Sarcolemma Contractile Muscle Fiber Intermediate Filament Cytoskeleton Cell Tip Extracellular Exosome Cardiac Myofibril Supramolecular Fiber
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Inflammatory Response DNA Damage Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Stabilization Inner Ear Development Positive Regulation Of Macrophage Cytokine Production 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	Muscle Contraction Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization Skeletal Muscle Organ Development
Pathways		p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Regulation of TNFR1 signaling	Striated Muscle Contraction
Drugs		Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM)
GWAS		Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)
Interacting Genes		42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1	58 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CDC73 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I YES1 ZMYM5
Entrez ID		9261	1674
HPRD ID		11882	00514
Ensembl ID		ENSG00000162889	ENSG00000175084
Uniprot IDs		P49137	P17661 Q53SB5
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6T8X 6TCA 7NRY 8XU4 8XX1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Intracellular Signaling Cassette RNA Stabilization Regulation Of RNA Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression P38MAPK Cascade Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Oxygen Levels Regulation Of Metabolic Process Nucleus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of MRNA Stability Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Peptide RNA Metabolic Process Regulation Of MRNA Metabolic Process Animal Organ Development MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Multicellular Organismal Process Negative Regulation Of Autophagy Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Macromolecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Stress	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Structural Molecule Activity Contractile Muscle Fiber Cytoskeleton Organization M Band Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Z Disc Supramolecular Fiber Organization Keratin Filament Cytoplasm Intermediate Filament Cytoskeleton Cornified Envelope Tissue Morphogenesis Organelle Organization Morphogenesis Of An Epithelium Extracellular Exosome Anterograde Axonal Transport
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