MAPKAPK2 and TSC2

Number of citations of the paper that reports this interaction (PubMedID 12582162)
0

Data Source:
HPRD (in vitro, in vivo)

		MAPKAPK2	TSC2
Description		MAPK activated protein kinase 2	TSC complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Ciliary Basal Body Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Inflammatory Response DNA Damage Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Stabilization Inner Ear Development Positive Regulation Of Macrophage Cytokine Production 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Regulation of TNFR1 signaling	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs		Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		9261	7249
HPRD ID		11882	01850
Ensembl ID		ENSG00000162889	ENSG00000103197
Uniprot IDs		P49137	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6T8X 6TCA 7NRY 8XU4 8XX1	7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Intracellular Signaling Cassette RNA Stabilization Regulation Of RNA Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression P38MAPK Cascade Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Oxygen Levels Regulation Of Metabolic Process Nucleus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of MRNA Stability Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Peptide RNA Metabolic Process Regulation Of MRNA Metabolic Process Animal Organ Development MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Multicellular Organismal Process Negative Regulation Of Autophagy Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Macromolecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Stress	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity
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