MAPKAPK2 and ARPC5

Number of citations of the paper that reports this interaction (PubMedID 12829704)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MAPKAPK2	ARPC5
Description		MAPK activated protein kinase 2	actin related protein 2/3 complex subunit 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Ciliary Basal Body Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Cortical Cytoskeleton Secretory Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Inflammatory Response DNA Damage Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Stabilization Inner Ear Development Positive Regulation Of Macrophage Cytokine Production 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation
Pathways		p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Regulation of TNFR1 signaling	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1	6 interacting genes: ACTR2 ACTR3 ARPC1B ARPC4 MAPKAPK2 NR3C1
Entrez ID		9261	10092
HPRD ID		11882	11969
Ensembl ID		ENSG00000162889	ENSG00000162704
Uniprot IDs		P49137	O15511
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6T8X 6TCA 7NRY 8XU4 8XX1	6UHC 6YW7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Intracellular Signaling Cassette RNA Stabilization Regulation Of RNA Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression P38MAPK Cascade Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Oxygen Levels Regulation Of Metabolic Process Nucleus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of MRNA Stability Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Peptide RNA Metabolic Process Regulation Of MRNA Metabolic Process Animal Organ Development MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Multicellular Organismal Process Negative Regulation Of Autophagy Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Macromolecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Stress	Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Actin Filament Binding Meiotic Chromosome Movement Towards Spindle Pole Actin Filament Organization Actin Cytoskeleton Meiotic Cytokinesis Actin Binding Site Of Double-strand Break Asymmetric Cell Division Supramolecular Fiber Organization Cytoskeleton Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Extracellular Exosome Regulation Of Lamellipodium Organization Spindle Localization Cellular Response To Type II Interferon Focal Adhesion Nuclear Glucocorticoid Receptor Activity Cell Division Tubulobulbar Complex Chromosome Localization Cytoskeleton-dependent Cytokinesis Response To Type II Interferon Response To Cytokine Response To Peptide Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Cell Cycle Cytosol Establishment Or Maintenance Of Cell Polarity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Actin Cap Nuclear Receptor-mediated Corticosteroid Signaling Pathway Response To Lipid Steroid Hormone Binding Calcium-dependent Protein Serine/threonine Kinase Activity Response To Cortisol Macropinocytosis Actin Polymerization-dependent Cell Motility Nucleus Regulation Of Cell Projection Assembly Mammary Gland Duct Morphogenesis Microglia Differentiation Cilium Assembly Regulation Of Glucocorticoid Biosynthetic Process Cellular Response To Growth Factor Stimulus
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