MAPKAPK2 and HNRNPA0

Number of citations of the paper that reports this interaction (PMID 12456657)
41

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MAPKAPK2	HNRNPA0
Gene Name		mitogen-activated protein kinase-activated protein kinase 2	heterogeneous nuclear ribonucleoprotein A0
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding	Nucleotide Binding RNA Binding AU-rich Element Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Leukotriene Metabolic Process Response To Stress Inflammatory Response Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Gene Expression Peptidyl-serine Phosphorylation Arachidonic Acid Metabolic Process G2 DNA Damage Checkpoint Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inner Ear Development Stress-activated MAPK Cascade 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	MRNA Splicing, Via Spliceosome MRNA Processing Inflammatory Response RNA Splicing Gene Expression Response To Lipopolysaccharide 3'-UTR-mediated MRNA Stabilization
Pathways		Signalling to ERKs CREB phosphorylation Metabolism of lipids and lipoproteins Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Arachidonic acid metabolism Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signalling by NGF Regulation of mRNA stability by proteins that bind AU-rich elements MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Regulation of HSF1-mediated heat shock response Synthesis of Leukotrienes (LT) and Eoxins (EX) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs		Staurosporine Adenosine-5\'-Diphosphate 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5\',6\':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		32 interactors: AKT1 ALOX5 ARPC5 BAG2 CDC25B CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK1 MAPK14 MAPK3 PABPC1 PARN PHC2 PIAS2 SHC1 SRF TCF3 TH TSC2 UBE2J1 YWHAZ ZFP36 ZFP36L1	15 interactors: CCT3 CIRBP DDX5 HNRNPF HNRNPH2 HNRNPH3 HNRNPK IL7R MAPK6 MAPKAPK2 MTNR1A MTNR1B NKX3-1 SRSF1 U2AF2
Entrez ID		9261	10949
HPRD ID		11882	17112
Ensembl ID		ENSG00000162889	ENSG00000177733
Uniprot IDs		P49137	Q13151
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Response To External Stimulus Defense Response Platelet Activation Posttranscriptional Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gene Expression Fc Receptor Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Regulation Of MRNA Stability Response To Peptide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cell Activation Regulation Of RNA Stability Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Neurotrophin Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels MRNA Stabilization Insulin Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Transcription, DNA-templated Innate Immune Response Chemotaxis Response To Growth Factor Blood Coagulation Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Hemostasis ERBB Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Peptide Hormone	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of RNA Splicing Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Gene Expression MRNA Stabilization Positive Regulation Of Gene Expression RNA Metabolic Process Termination Of RNA Polymerase II Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus MRNA Export From Nucleus Regulation Of Gene Expression DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Interleukin-7-mediated Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Androgen Secretion Regulation Of Lipid Transport Transcription From RNA Polymerase II Promoter Negative Regulation Of Estrogen Receptor Binding RNA 3'-end Processing Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus MRNA 5'-splice Site Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Nucleobase-containing Compound Metabolic Process RNA Transport Cell Growth G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macropinocytosis Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Binding
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates posttranscriptional releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates posttranscriptional releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired
Tagcloud (Intersection) ?