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MAPKAPK2
Gene Name
mitogen-activated protein kinase-activated protein kinase 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Signal Transducer Activity
Protein Binding
ATP Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Leukotriene Metabolic Process
Response To Stress
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Ras Protein Signal Transduction
Gene Expression
Peptidyl-serine Phosphorylation
Arachidonic Acid Metabolic Process
G2 DNA Damage Checkpoint
Response To Lipopolysaccharide
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Response To Cytokine
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Heat
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Small Molecule Metabolic Process
Macropinocytosis
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Inner Ear Development
Stress-activated MAPK Cascade
3'-UTR-mediated MRNA Stabilization
Regulation Of Cellular Response To Heat
Pathways
Signalling to ERKs
CREB phosphorylation
Metabolism of lipids and lipoproteins
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
CREB phosphorylation
VEGFA-VEGFR2 Pathway
Toll Like Receptor TLR6:TLR2 Cascade
Arachidonic acid metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
p38MAPK events
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Innate Immune System
Signalling by NGF
Regulation of mRNA stability by proteins that bind AU-rich elements
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Tristetraprolin (TTP) destabilizes mRNA
NGF signalling via TRKA from the plasma membrane
Cellular response to heat stress
Regulation of HSF1-mediated heat shock response
Synthesis of Leukotrienes (LT) and Eoxins (EX)
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Signaling by VEGF
Oxidative Stress Induced Senescence
Signalling to RAS
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Staurosporine
Adenosine-5\'-Diphosphate
3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE
(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5\',6\':4,5]thieno[3,2-f]quinolin-8-one
(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-protein Interactions
32 interactors:
AKT1
ALOX5
ARPC5
BAG2
CDC25B
CREB1
DDX5
DES
EEF2K
ETV1
HNRNPA0
HSF1
HSPB1
LIMK1
LSP1
MAP2K6
MAPK1
MAPK14
MAPK3
PABPC1
PARN
PHC2
PIAS2
SHC1
SRF
TCF3
TH
TSC2
UBE2J1
YWHAZ
ZFP36
ZFP36L1
Entrez ID
9261
HPRD ID
11882
Ensembl ID
ENSG00000162889
Uniprot IDs
P49137
PDB IDs
1KWP
1NXK
1NY3
2JBO
2JBP
2OKR
2ONL
2OZA
2P3G
2PZY
3A2C
3FPM
3FYJ
3FYK
3GOK
3KA0
3KC3
3KGA
3M2W
3M42
3R2B
3R2Y
3R30
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Macromolecule Biosynthetic Process
Response To External Stimulus
Defense Response
Platelet Activation
Posttranscriptional Regulation Of Gene Expression
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Gene Expression
Fc Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Response To Stress
Regulation Of MRNA Stability
Response To Peptide
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cell Activation
Regulation Of RNA Stability
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Neurotrophin Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Growth Factor Stimulus
Regulation Of Body Fluid Levels
MRNA Stabilization
Insulin Receptor Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Transcription, DNA-templated
Innate Immune Response
Chemotaxis
Response To Growth Factor
Blood Coagulation
Regulation Of Cellular Protein Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Hemostasis
ERBB Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Peptide Hormone
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pak2
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles