MITF and HINT1

Number of citations of the paper that reports this interaction (PMID 22647378)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MITF	HINT1
Gene Name		microphthalmia-associated transcription factor	histidine triad nucleotide binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Protein Complex	Histone Deacetylase Complex Nucleus Cytoplasm Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	Nucleotide Binding Protein Kinase C Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways
Drugs			Adenosine monophosphate Guanosine-5\'-Monophosphate 5\'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5\'-Ditungstate 8-Bromo-Adenosine-5\'-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	4 interactors: CDC16 MITF SP1 TRIM29
Entrez ID		4286	3094
HPRD ID		01138	03204
Ensembl ID		ENSG00000187098
Uniprot IDs		B4DNC7 O75030 Q8WYR3	P49773
PDB IDs			1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated	Sequestering Of Nodal From Receptor Via Nodal Binding Transcription From RNA Polymerase II Promoter Negative Regulation Of Nodal Signaling Pathway Myeloid Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of Nodal Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation By Host Of Viral Transcription Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Lateral Mesoderm Development Enucleate Erythrocyte Differentiation Negative Regulation Of Cellular Metabolic Process Extracellular Negative Regulation Of Signal Transduction Transcription, DNA-templated Sensory Organ Development Atrial Septum Development Megakaryocyte Differentiation Regulation Of Activin Receptor Signaling Pathway Protein K11-linked Ubiquitination RNA Biosynthetic Process Definitive Hemopoiesis Hemopoiesis Trophectodermal Cell Differentiation Positive Regulation Of Cellular Metabolic Process Immune System Development Interaction With Symbiont Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter Melanocyte Differentiation Mitotic Spindle Checkpoint Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Chromosome Segregation Negative Regulation Of BMP Signaling Pathway Embryonic Eye Morphogenesis Osteoclast Differentiation Positive Regulation Of Viral Transcription Neuroepithelial Cell Differentiation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition RNA Metabolic Process Ventricular Septum Development
Tagcloud ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	attenuating beta1 capable catenin ccl4 dawley engineering exists fibrosis histidine histopathological hydroxyproline liver lowered pathogenic simultaneously sma smad smad3 smad7 sought sprague subcutaneous tetrachloride tgf transforming triad vital
Tagcloud (Difference) ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	attenuating beta1 capable catenin ccl4 dawley engineering exists fibrosis histidine histopathological hydroxyproline liver lowered pathogenic simultaneously sma smad smad3 smad7 sought sprague subcutaneous tetrachloride tgf transforming triad vital
Tagcloud (Intersection) ?