MITF and EBP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MITF	EBP
Gene Name		microphthalmia-associated transcription factor	emopamil binding protein (sterol isomerase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Protein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Transmembrane Signaling Receptor Activity Drug Transmembrane Transporter Activity Cholestenol Delta-isomerase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling	Skeletal System Development Cholesterol Biosynthetic Process Drug Transmembrane Transport Signal Transduction Cholesterol Metabolic Process Hemopoiesis Small Molecule Metabolic Process
Pathways			Cholesterol biosynthesis Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	4 interactors: APP EBPL ESRRG MITF
Entrez ID		4286	10682
HPRD ID		01138	02192
Ensembl ID		ENSG00000187098	ENSG00000147155
Uniprot IDs		B4DNC7 O75030 Q8WYR3	Q15125
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated	Sterol Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Steroid Metabolic Process Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axon Choice Point Recognition Positive Regulation Of Cellular Biosynthetic Process Alcohol Metabolic Process Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Neuron Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Melanocyte Differentiation
Tagcloud ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	af ccaat delta distinguish ebps encode enhancer glucocorticoid gr gst herpes indeed indistinguishably intermediary lbd mapped potentiated potentiation pull rars reciprocally repress responsiveness simplex surprisingly thymidine truncation unable ways
Tagcloud (Difference) ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	af ccaat delta distinguish ebps encode enhancer glucocorticoid gr gst herpes indeed indistinguishably intermediary lbd mapped potentiated potentiation pull rars reciprocally repress responsiveness simplex surprisingly thymidine truncation unable ways
Tagcloud (Intersection) ?