MITF and TFEB

Number of citations of the paper that reports this interaction (PubMedID 9806910)
0

Data Source:
HPRD (in vivo)

		MITF	TFEB
Description		melanocyte inducing transcription factor	transcription factor EB
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Protein-containing Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Apoptotic Process Pigmentation Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Melanocyte Apoptotic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Biosynthetic Process	Embryonic Placenta Development Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Autophagy Humoral Immune Response Lysosome Organization Cellular Response To Starvation Positive Regulation Of Autophagy Lysosome Localization Cellular Response To Amino Acid Starvation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Antibacterial Innate Immune Response Regulation Of Lysosome Organization
Pathways		SUMOylation of transcription factors Transcriptional and post-translational regulation of MITF-M expression and activity	Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases		Malignant melanoma Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS)
GWAS		Apolipoprotein B levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 32888494 27863252) Renal underexcretion gout ( 32238385) Severe influenza A (H1N1) infection ( 26379185) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)	Attention deficit hyperactivity disorder ( 18839057) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 26965516 30529582) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Late-onset Alzheimer's disease ( 27770636) PR interval ( 32439900) White blood cell count ( 32888494)
Interacting Genes		33 interacting genes: ADRB2 APP BTRC CLK4 CTNNB1 EBP EP300 FBXO7 FBXW11 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	5 interacting genes: CFTR MITF SRPK1 TFE3 TFEC
Entrez ID		4286	7942
HPRD ID		01138	02847
Ensembl ID		ENSG00000187098	ENSG00000112561
Uniprot IDs		A0A087WXU1 A0A8I5KSZ4 B4DNC7 O75030	B0QYS6 P19484
PDB IDs		4C7N 7D8R 7D8S 7D8T 7EOD 8E1D	7UX2 7UXC 7UXH 7Y62
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of RNA Metabolic Process Enzyme Binding Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Post-translational Protein Modification Protein Sumoylation Cell Surface Receptor Signaling Pathway SUMO Transferase Activity Positive Regulation Of Cell Differentiation Chromatin Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Negative Regulation Of Intracellular Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Presynaptic Cytosol Postsynaptic Cytosol Chromatin Binding	Protein Dimerization Activity Lysosomal Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Osteoclast Differentiation Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Response To Interleukin-12 Positive Regulation Of Anion Channel Activity Melanocyte Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Monoatomic Anion Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Thrombospondin Receptor Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monocyte Extravasation Transepithelial Water Transport ATP Export Fibrinogen Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Myeloid Cell Differentiation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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