MITF and TFEC

Number of citations of the paper that reports this interaction (PubMedID 11818452)
0

Data Source:
HPRD (in vivo)

		MITF	TFEC
Description		melanocyte inducing transcription factor	transcription factor EC
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Apoptotic Process Pigmentation Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Melanocyte Apoptotic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of transcription factors Transcriptional and post-translational regulation of MITF-M expression and activity	Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Malignant melanoma Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS)
GWAS		Apolipoprotein B levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 32888494 27863252) Renal underexcretion gout ( 32238385) Severe influenza A (H1N1) infection ( 26379185) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)	Body mass index ( 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intraocular pressure ( 29235454 29617998 29785010) Number of sexual partners ( 30643258) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Tonsillectomy ( 27182965 28928442)
Interacting Genes		33 interacting genes: ADRB2 APP BTRC CLK4 CTNNB1 EBP EP300 FBXO7 FBXW11 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	11 interacting genes: DCK DEFB127 HNRNPA1 LPAR3 MITF NAPB SMCO4 TET2 TFE3 TFEB ZMAT2
Entrez ID		4286	22797
HPRD ID		01138	05294
Ensembl ID		ENSG00000187098	ENSG00000105967
Uniprot IDs		A0A087WXU1 A0A8I5KSZ4 B4DNC7 O75030	O14948
PDB IDs		4C7N 7D8R 7D8S 7D8T 7EOD 8E1D
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of RNA Metabolic Process Enzyme Binding Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Post-translational Protein Modification Protein Sumoylation Cell Surface Receptor Signaling Pathway SUMO Transferase Activity Positive Regulation Of Cell Differentiation Chromatin Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Negative Regulation Of Intracellular Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Presynaptic Cytosol Postsynaptic Cytosol Chromatin Binding	Deoxyguanosine Kinase Activity Deoxynucleoside Kinase Activity Deoxyadenosine Kinase Activity Deoxycytidine Kinase Activity DAMP Salvage Telomeric Repeat-containing RNA Binding DNA Binding Protein Dimerization Activity Melanocyte Apoptotic Process Lysosomal Membrane Regulation Of Osteoclast Differentiation Lysosome Organization Humoral Immune Response Defense Response To Gram-negative Bacterium DNA 5-methylcytosine Dioxygenase Activity Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Cytidine Kinase Activity CMP Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lysophosphatidic Acid Receptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Sodium Arsenite Lysosome
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