MITF and TFEC

Number of citations of the paper that reports this interaction (PMID 11818452)
8

Data Source:
HPRD (in vivo)

		MITF	TFEC
Gene Name		microphthalmia-associated transcription factor	transcription factor EC
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Protein Complex	Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To Heat Negative Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	8 interactors: DCK DEFB127 HNRNPA1 MITF NAPB TFE3 TFEB ZMAT2
Entrez ID		4286	22797
HPRD ID		01138	05294
Ensembl ID		ENSG00000187098	ENSG00000105967
Uniprot IDs		B4DNC7 O75030 Q8WYR3	O14948
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated	Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Myeloid Cell Differentiation SNARE Complex Disassembly Humoral Immune Response Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Purine-containing Compound Salvage Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process
Tagcloud ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	advantage agonists augment autonomous believed competitive confer conservation define determinants engineered enhance fos hsc hscs intrinsically klf10 majority namely niches osteoclastogenesis prdm16 renewal robust screen spi1 supports surprisingly unexpectedly
Tagcloud (Difference) ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	advantage agonists augment autonomous believed competitive confer conservation define determinants engineered enhance fos hsc hscs intrinsically klf10 majority namely niches osteoclastogenesis prdm16 renewal robust screen spi1 supports surprisingly unexpectedly
Tagcloud (Intersection) ?