LACRT and FN1

Number of citations of the paper that reports this interaction (PMID 11419941)
22

Data Source:
HPRD (in vitro)

		LACRT	FN1
Gene Name		lacritin	fibronectin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Glycoprotein Binding Fibronectin Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Positive Regulation Of Cell Proliferation Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Tear Secretion	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration
Pathways			Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP FN1 NID1 SDC1 VTN	96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL
Entrez ID		90070	2335
HPRD ID		06302	00626
Ensembl ID		ENSG00000135413	ENSG00000115414
Uniprot IDs		Q9GZZ8	P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6
PDB IDs			1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Cell-substrate Adhesion Endodermal Cell Differentiation Cell Adhesion Defense Response Regulation Of Peptidase Activity Endoderm Formation Platelet Degranulation Endoderm Development Extracellular Matrix Disassembly Wound Healing Regulation Of Proteolysis Response To Wounding Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Multicellular Organismal Development Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Myoblast Development Anatomical Structure Morphogenesis Collateral Sprouting In Absence Of Injury Gastrulation Platelet Activation Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extracellular Vesicular Exosome Assembly Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Axon Choice Point Recognition Regulation Of Developmental Growth Positive Regulation Of Proteolysis Kidney Development Renal System Development Neuron Remodeling Cell Differentiation Response To Light Stimulus Exocytosis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis
Tagcloud ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Difference) ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Intersection) ?