LACRT and NID1

Number of citations of the paper that reports this interaction (PMID 11419941)
22

Data Source:
HPRD (in vitro)

		LACRT	NID1
Gene Name		lacritin	nidogen 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Basement Membrane Basal Lamina Extracellular Matrix Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Glycoprotein Binding Fibronectin Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Positive Regulation Of Cell Proliferation Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Tear Secretion	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways			Laminin interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Cutaneous nevi ( 21478494)
Protein-Protein Interactions		5 interactors: APP FN1 NID1 SDC1 VTN	21 interactors: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		90070	4811
HPRD ID		06302	00574
Ensembl ID		ENSG00000135413	ENSG00000116962
Uniprot IDs		Q9GZZ8	P14543
PDB IDs			1NDX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Cell-substrate Adhesion Endodermal Cell Differentiation Cell Adhesion Defense Response Regulation Of Peptidase Activity Endoderm Formation Platelet Degranulation Endoderm Development Extracellular Matrix Disassembly Wound Healing Regulation Of Proteolysis Response To Wounding Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Multicellular Organismal Development Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Myoblast Development Anatomical Structure Morphogenesis Collateral Sprouting In Absence Of Injury Gastrulation Platelet Activation Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extracellular Vesicular Exosome Assembly Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Axon Choice Point Recognition Regulation Of Developmental Growth Positive Regulation Of Proteolysis Kidney Development Renal System Development Neuron Remodeling Cell Differentiation Response To Light Stimulus Exocytosis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cell Adhesion Regulation Of Body Fluid Levels Cell-substrate Adhesion Blood Coagulation Hemostasis Blood Vessel Development Vasculature Development Cell-matrix Adhesion Platelet Degranulation Locomotion Wound Healing Chemotaxis Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Blood Vessel Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Axonogenesis Platelet Aggregation Cardiovascular System Development Tissue Development Retinal Blood Vessel Morphogenesis Endochondral Ossification Axon Development Substrate Adhesion-dependent Cell Spreading Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-substrate Junction Assembly Neuron Projection Morphogenesis Vesicle-mediated Transport Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Collagen Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Lipoprotein Metabolic Process Multicellular Organismal Development
Tagcloud ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Difference) ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Intersection) ?