LACRT and NID1

Number of citations of the paper that reports this interaction (PubMedID 11419941)
0

Data Source:
HPRD (in vitro)

		LACRT	NID1
Description		lacritin	nidogen 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Protein Binding Collagen Binding Growth Factor Activity Laminin-1 Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Macroautophagy Calcium-mediated Signaling Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Tear Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs			Urokinase
Diseases
GWAS			Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		6 interacting genes: APP FN1 NID1 SDC1 TGM2 VTN	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		90070	4811
HPRD ID		06302	00574
Ensembl ID		ENSG00000135413	ENSG00000116962
Uniprot IDs		Q9GZZ8	P14543
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidase Activator Activity Golgi Lumen Extracellular Region Extracellular Exosome Collagen Binding Extracellular Matrix Basement Membrane Cell-matrix Adhesion Protein Complex Involved In Cell-matrix Adhesion Extracellular Matrix Structural Constituent Positive Regulation Of Cell-substrate Adhesion Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Integrin Binding Cellular Response To Catecholamine Stimulus Regulation Of Vesicle-mediated Transport Heparin Binding Cell-substrate Adhesion Response To Catecholamine Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Adhesion Endodermal Cell Differentiation Cell Adhesion Positive Regulation Of Cell Differentiation Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Platelet Alpha Granule Lumen Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Vesicle-mediated Transport Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength
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