LACRT and VTN

Number of citations of the paper that reports this interaction (PMID 11419941)
22

Data Source:
HPRD (in vitro)

		LACRT	VTN
Gene Name		lacritin	vitronectin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Glycoprotein Binding Fibronectin Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding
	Biological Process	Positive Regulation Of Cell Proliferation Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Tear Secretion	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways			Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System
Drugs			Abciximab
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP FN1 NID1 SDC1 VTN	42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA
Entrez ID		90070	7448
HPRD ID		06302	01902
Ensembl ID		ENSG00000135413
Uniprot IDs		Q9GZZ8	D9ZGG2 P04004
PDB IDs			1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Cell-substrate Adhesion Endodermal Cell Differentiation Cell Adhesion Defense Response Regulation Of Peptidase Activity Endoderm Formation Platelet Degranulation Endoderm Development Extracellular Matrix Disassembly Wound Healing Regulation Of Proteolysis Response To Wounding Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Multicellular Organismal Development Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Myoblast Development Anatomical Structure Morphogenesis Collateral Sprouting In Absence Of Injury Gastrulation Platelet Activation Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extracellular Vesicular Exosome Assembly Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Axon Choice Point Recognition Regulation Of Developmental Growth Positive Regulation Of Proteolysis Kidney Development Renal System Development Neuron Remodeling Cell Differentiation Response To Light Stimulus Exocytosis	Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Difference) ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Intersection) ?