LACRT and SDC1

Number of citations of the paper that reports this interaction (PMID 16982797)
20

Data Source:
HPRD (in vitro)

		LACRT	SDC1
Gene Name		lacritin	syndecan 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Fibronectin Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Glycoprotein Binding Protein Binding Protein C-terminus Binding
	Biological Process	Positive Regulation Of Cell Proliferation Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Tear Secretion	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Phototransduction, Visible Light Pathogenesis Response To Toxic Substance Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Wound Healing Lipoprotein Metabolic Process Odontogenesis Response To Hydrogen Peroxide Small Molecule Metabolic Process Myoblast Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways			Lipoprotein metabolism MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Metabolism of lipids and lipoproteins Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Lipid digestion, mobilization, and transport Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Syndecan interactions Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP FN1 NID1 SDC1 VTN	15 interactors: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTN SDCBP
Entrez ID		90070	6382
HPRD ID		06302	01718
Ensembl ID		ENSG00000135413	ENSG00000115884
Uniprot IDs		Q9GZZ8	P18827
PDB IDs			4GVC 4GVD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Cell-substrate Adhesion Endodermal Cell Differentiation Cell Adhesion Defense Response Regulation Of Peptidase Activity Endoderm Formation Platelet Degranulation Endoderm Development Extracellular Matrix Disassembly Wound Healing Regulation Of Proteolysis Response To Wounding Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Multicellular Organismal Development Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Myoblast Development Anatomical Structure Morphogenesis Collateral Sprouting In Absence Of Injury Gastrulation Platelet Activation Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Extracellular Vesicular Exosome Assembly Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Axon Choice Point Recognition Regulation Of Developmental Growth Positive Regulation Of Proteolysis Kidney Development Renal System Development Neuron Remodeling Cell Differentiation Response To Light Stimulus Exocytosis	Cell Migration Locomotion Cell Motility Positive Regulation Of Cellular Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Behavior Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Lipid Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Response To Stress Positive Chemotaxis Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Chemotaxis Interaction With Symbiont Regulation Of Growth Positive Regulation Of Cell Migration Regulation Of Protein Metabolic Process Regulation Of Chemotaxis Positive Regulation Of Cell Motility Secretion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Killing By Host Of Symbiont Cells Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Platelet Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Organ Development Regulation Of Body Fluid Levels
Tagcloud ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Difference) ?		acinar ago americans applicability coacervate coacervates dacryoadenitis depot durability elastin elp hexosaminidase illustrated inspired lacrimal millions motivated ocular polymers prosecretory reversibly suffer tear tears thermo tropoelastin tunable viscous	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Intersection) ?