RECQL5 and TIMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RECQL5	TIMP1
Description		RecQ like helicase 5	TIMP metallopeptidase inhibitor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA	Protease Binding Enzyme Inhibitor Activity Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Cellular Response To Peptide Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways			Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5 UBC
Entrez ID		9400	7076
HPRD ID		04806	02371
Ensembl ID		ENSG00000108469	ENSG00000102265
Uniprot IDs		B3KQK2 O94762	P01033 Q6FGX5
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4	1D2B 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D 7S7L 7S7M
Enriched GO Terms of Interacting Partners?		Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair	Cellular Response To UV-A Response To UV-A Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Metalloendopeptidase Activity Endopeptidase Activity Cellular Response To UV Cellular Response To Light Stimulus Metallopeptidase Activity Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Fibronectin Binding Extracellular Structure Organization Extracellular Matrix Organization Pigment Granule Maturation Extracellular Space Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity Response To Light Stimulus Response To Amyloid-beta Skeletal Muscle Hypertrophy Mitochondrion Cellular Response To Amino Acid Stimulus Regulation Of Cell Migration Mitotic DNA-templated DNA Replication Extracellular Matrix Regulation Of Cell Motility Response To Radiation Peptidase Activity Cellular Pigment Accumulation Regulation Of Locomotion Catabolic Process Cellular Response To Reactive Oxygen Species Mitotic DNA Replication Response To Amino Acid Positive Regulation Of Cellular Component Organization Cellular Pigmentation Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Catalytic Activity, Acting On DNA Proteolysis Extracellular Region Multivesicular Body, Internal Vesicle Isomerase Activity Clustering Of Voltage-gated Sodium Channels Cellular Response To Camptothecin Platelet Dense Granule Membrane Intramembranous Ossification
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