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RECQL5 and MRE11A
Number of citations of the paper that reports this interaction (PMID
19270065
)
16
Data Source:
BioGRID
(pull down)
RECQL5
MRE11A
Gene Name
RecQ protein-like 5
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
DNA-directed RNA Polymerase II, Holoenzyme
Nuclear Membrane
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytosol
Mre11 Complex
Site Of Double-strand Break
Molecular Function
RNA Polymerase II Core Binding
Nucleic Acid Binding
DNA Helicase Activity
ATP Binding
ATP-dependent Helicase Activity
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
Double-stranded DNA Binding
ATP-dependent DNA Helicase Activity
Nuclease Activity
Endonuclease Activity
Endodeoxyribonuclease Activity
Protein Binding
Protein C-terminus Binding
3'-5' Exonuclease Activity
Manganese Ion Binding
Biological Process
DNA Metabolic Process
DNA Replication
DNA Repair
DNA Recombination
Mitotic Nuclear Division
DNA Duplex Unwinding
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Cell Division
Chromosome Separation
Regulation Of Mitotic Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Catabolic Process, Endonucleolytic
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Sister Chromatid Cohesion
Mitotic G2 DNA Damage Checkpoint
Synapsis
Reciprocal Meiotic Recombination
Cell Proliferation
Intra-S DNA Damage Checkpoint
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Negative Regulation Of DNA Endoreduplication
Positive Regulation Of Kinase Activity
Innate Immune Response
Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
MRN complex relocalizes to nuclear foci
Cytosolic sensors of pathogen-associated DNA
Cellular Senescence
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
Homologous Recombination Repair
STING mediated induction of host immune responses
Homologous recombination repair of replication-independent double-strand breaks
Recruitment of repair and signaling proteins to double-strand breaks
Double-Strand Break Repair
IRF3-mediated induction of type I IFN
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
19 interactors:
ADCY10P1
ALDH7A1
BNIPL
CREB1
CUX1
DDX42
EEF1G
ITGB3BP
MAPK8IP1
MRE11A
MTSS1
NBN
PLK1
POLR2A
RAD50
STAMBP
TIMP1
TOP3A
TOP3B
16 interactors:
ATM
ATR
BRCA1
CCNE1
DCLRE1C
EP300
FANCD2
H2AFX
LIG1
NBN
NEK1
PRKDC
RAD50
RBBP8
RECQL5
XRCC6
Entrez ID
9400
4361
HPRD ID
04806
02889
Ensembl ID
ENSG00000108469
ENSG00000020922
Uniprot IDs
B3KQK2
O94762
Q6P4G0
Q8WYH5
B3KTC7
P49959
Q05D78
PDB IDs
4BK0
3T1I
Enriched GO Terms of Interacting Partners
?
DNA Conformation Change
Positive Regulation Of Protein Autophosphorylation
Meiotic Cell Cycle
Regulation Of Protein Autophosphorylation
G2 DNA Damage Checkpoint
Chromosome Organization
Cellular Response To Stress
Meiotic Nuclear Division
Regulation Of Mitotic Recombination
Telomere Maintenance
Telomere Maintenance Via Telomerase
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Cell Cycle
Mitotic G2 DNA Damage Checkpoint
Cell Cycle Process
DNA Metabolic Process
Mitotic Cell Cycle Process
DNA Topological Change
RNA-dependent DNA Replication
Organelle Organization
Double-strand Break Repair
Mitotic Cell Cycle
DNA Damage Checkpoint
Regulation Of Kinase Activity
Mitotic Cell Cycle Checkpoint
Telomere Maintenance Via Telomere Lengthening
Cellular Response To DNA Damage Stimulus
Response To Stress
Mitotic Cytokinesis
Reciprocal Meiotic Recombination
Negative Regulation Of Mitotic Cell Cycle
Chromosome Segregation
Cell Cycle Checkpoint
DNA Recombination
Positive Regulation Of Transferase Activity
Reproduction
DNA Repair
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Regulation Of DNA Recombination
Cellular Nitrogen Compound Metabolic Process
Activation Of APC-Cdc20 Complex Activity
Transcription, RNA-templated
Glycine Betaine Biosynthetic Process From Choline
Adherens Junction Maintenance
Positive Regulation Of Cellular Metabolic Process
Cell Proliferation
DNA Recombination
Double-strand Break Repair
Cellular Response To DNA Damage Stimulus
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Recombinational Repair
Cell Cycle Process
DNA Metabolic Process
Cellular Response To Stress
Response To Ionizing Radiation
Cell Cycle
Telomere Maintenance
Organelle Organization
Response To Radiation
Chromosome Organization
DNA Damage Checkpoint
Response To Stress
Cell Cycle Checkpoint
Response To Abiotic Stimulus
Nucleobase-containing Compound Metabolic Process
Mitotic Cell Cycle
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
V(D)J Recombination
Cellular Response To Stimulus
Meiotic Cell Cycle
Nitrogen Compound Metabolic Process
Mitotic Cell Cycle Process
G2 DNA Damage Checkpoint
DNA Replication
Response To Gamma Radiation
Response To Stimulus
Positive Regulation Of Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair Via Nonhomologous End Joining
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
DNA Conformation Change
Signal Transduction By P53 Class Mediator
Regulation Of Cellular Response To Heat
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Regulation Of Response To DNA Damage Stimulus
Apoptotic Signaling Pathway
Reproduction
B Cell Activation
Regulation Of Protein Metabolic Process
Tagcloud
?
5yrs
atm
atr
brfr
category
cohorts
ddr
decisions
fail
gains
gleason
guided
igrt
nbn
nibrin
pca
precision
predictor
predicts
prkdc
prostatectomy
psa
rad50
radioresistance
radiotherapy
radp
sensing
sensors
wald
Tagcloud (Difference)
?
5yrs
atm
atr
brfr
category
cohorts
ddr
decisions
fail
gains
gleason
guided
igrt
nbn
nibrin
pca
precision
predictor
predicts
prkdc
prostatectomy
psa
rad50
radioresistance
radiotherapy
radp
sensing
sensors
wald
Tagcloud (Intersection)
?