RECQL5 and ALDH7A1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RECQL5	ALDH7A1
Gene Name		RecQ protein-like 5	aldehyde dehydrogenase 7 family, member A1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm DNA-directed RNA Polymerase II, Holoenzyme Nuclear Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding ATP-dependent Helicase Activity	Aldehyde Dehydrogenase (NAD) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase Activity
	Biological Process	DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Mitotic Nuclear Division DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation	Cellular Aldehyde Metabolic Process Lysine Catabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Lysine catabolism Metabolism of amino acids and derivatives
Drugs			NADH
Diseases
GWAS			Osteoporosis ( 20072603)
Protein-Protein Interactions		19 interactors: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11A MTSS1 NBN PLK1 POLR2A RAD50 STAMBP TIMP1 TOP3A TOP3B	3 interactors: APP EPS8 RECQL5
Entrez ID		9400	501
HPRD ID		04806	00124
Ensembl ID		ENSG00000108469	ENSG00000164904
Uniprot IDs		B3KQK2 O94762 Q6P4G0 Q8WYH5	P49419
PDB IDs		4BK0	2J6L
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Positive Regulation Of Protein Autophosphorylation Meiotic Cell Cycle Regulation Of Protein Autophosphorylation G2 DNA Damage Checkpoint Chromosome Organization Cellular Response To Stress Meiotic Nuclear Division Regulation Of Mitotic Recombination Telomere Maintenance Telomere Maintenance Via Telomerase DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Mitotic G2 DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Mitotic Cell Cycle Process DNA Topological Change RNA-dependent DNA Replication Organelle Organization Double-strand Break Repair Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Telomere Maintenance Via Telomere Lengthening Cellular Response To DNA Damage Stimulus Response To Stress Mitotic Cytokinesis Reciprocal Meiotic Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Transferase Activity Reproduction DNA Repair Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Activation Of APC-Cdc20 Complex Activity Transcription, RNA-templated Glycine Betaine Biosynthetic Process From Choline Adherens Junction Maintenance Positive Regulation Of Cellular Metabolic Process Cell Proliferation	Adult Locomotory Behavior Adult Behavior Synaptic Growth At Neuromuscular Junction Locomotory Behavior Collateral Sprouting In Absence Of Injury Actin Polymerization-dependent Cell Motility Mitotic Nuclear Division Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Exit From Mitosis Single-organism Behavior Neuron Remodeling Behavioral Response To Ethanol Behavior Rac Protein Signal Transduction Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Copper Ion Homeostasis Negative Regulation Of DNA-templated Transcription, Elongation Mitotic Cell Cycle Process Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Chromosome Separation Copper Ion Homeostasis Suckling Behavior Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription Elongation From RNA Polymerase II Promoter RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Cycle Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Actin Filament Capping Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Actin Filament Depolymerization Neuron Apoptotic Process
Tagcloud ?			accumulating aldehyde associate carcinomas clearly counterparts dehydrogense demonstrates dramatic du145 elevation former glands isoforms local metastatic paired pc pcscs pin prostate robust stained tumorigenesis tumours xenograft
Tagcloud (Difference) ?			accumulating aldehyde associate carcinomas clearly counterparts dehydrogense demonstrates dramatic du145 elevation former glands isoforms local metastatic paired pc pcscs pin prostate robust stained tumorigenesis tumours xenograft
Tagcloud (Intersection) ?