RECQL5 and TOP3A

Number of citations of the paper that reports this interaction (PubMedID 10710432)
40

Data Source:
HPRD (in vitro, in vivo)

		RECQL5	TOP3A
Description		RecQ like helicase 5	DNA topoisomerase III alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex	Nucleus Nucleoplasm Chromosome Mitochondrion Mitochondrial Matrix PML Body RecQ Family Helicase-topoisomerase III Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding Isomerase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Double-strand Break Repair Via Homologous Recombination DNA Topological Change DNA Repair DNA Recombination Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle Resolution Of DNA Recombination Intermediates
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)	Systolic blood pressure ( 30224653)
Interacting Genes		21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	3 interacting genes: BLM RECQL5 TDRD3
Entrez ID		9400	7156
HPRD ID		04806	03145
Ensembl ID		ENSG00000108469	ENSG00000177302
Uniprot IDs		B3KQK2 O94762	Q13472
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4	4CGY 4CHT
Enriched GO Terms of Interacting Partners?		Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair	Four-way Junction Helicase Activity Cellular Response To Camptothecin 3'-5' DNA Helicase Activity DNA Conformation Change Replication Fork Cellular Response To Alkaloid DNA Helicase Activity Negative Regulation Of DNA Recombination Response To Alkaloid DNA Metabolic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Recombinational Repair Helicase Activity Double-strand Break Repair Via Homologous Recombination DNA Replication Isomerase Activity Forked DNA-dependent Helicase Activity Mitotic DNA-templated DNA Replication Histone H3 Reader Activity DNA Topoisomerase III-beta-TDRD3 Complex 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Mitotic DNA Replication DNA Recombination RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Response To Alcohol Y-form DNA Binding Catalytic Activity, Acting On DNA Histone H4 Reader Activity Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Chromosome Organization Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change ATP Hydrolysis Activity Bubble DNA Binding Resolution Of DNA Recombination Intermediates Telomeric D-loop Disassembly G-quadruplex DNA Binding Nucleic Acid Metabolic Process DNA Topological Change Cellular Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Chromosome Separation T-circle Formation
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