CENPF and PLOD2

Data Source: HiPPIP (Novel)

		CENPF	PLOD2
Name		centromere protein F	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Rough Endoplasmic Reticulum Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process	Response To Hypoxia Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Collagen Fibril Organization Protein Modification Process Hydroxylysine Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Collagen biosynthesis and modifying enzymes
Drugs		None	Ascorbic acid
Diseases		None	Bruck syndrome
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Lung function (FVC) ( 30061609 ) Response to antineoplastic agents ( 21659360 ) Serum immune biomarker levels ( 32066700 )	Height ( 31562340 ) Obesity-related traits ( 23251661 ) Squamous cell lung carcinoma ( 28604730 ) Zinc levels ( 26025379 )
Novel Interactors		6 novel interactors: HSD11B1 IRF6 KLHL41 PLOD2 SLC30A1 SLC4A1AP	6 novel interactors: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1
Interacting Genes		12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B	1 interacting genes: LINC01554
Entrez ID		1063	5352
HPRD ID		02582	03519
Ensembl ID		ENSG00000117724	ENSG00000152952
Uniprot IDs		A0A9L9PXU7 P49454	A0A994J6S5 O00469
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion	None