CENPF and SLC30A1

Data Source: HiPPIP (Novel)

		CENPF	SLC30A1
Name		centromere protein F	solute carrier family 30 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane T-tubule Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Postsynaptic Density, Intracellular Component Glutamatergic Postsynaptic Density
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Calcium Channel Inhibitor Activity Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process	In Utero Embryonic Development Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Zinc Ion Defense Response To Bacterium Negative Regulation Of Neurotransmitter Secretion Transmembrane Transport Positive Regulation Of Dendritic Spine Morphogenesis Zinc Ion Import Into Organelle Calcium Ion Import Cadmium Ion Transmembrane Transport Zinc Ion Transmembrane Transport Negative Regulation Of Zinc Ion Transmembrane Import Detoxification Of Cadmium Ion Negative Regulation Of Calcium Ion Import Zinc Export Across Plasma Membrane Regulation Of Postsynaptic Density Protein 95 Clustering
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Zinc efflux and compartmentalization by the SLC30 family
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Lung function (FVC) ( 30061609 ) Response to antineoplastic agents ( 21659360 ) Serum immune biomarker levels ( 32066700 )	Appendicular lean mass ( 33097823 ) Hypertension ( 21347282 ) Nevus count ( 33959940 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		6 novel interactors: HSD11B1 IRF6 KLHL41 PLOD2 SLC30A1 SLC4A1AP	1 novel interactors: CENPF
Interacting Genes		12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B	2 interacting genes: MTNR1A MTNR1B
Entrez ID		1063	7779
HPRD ID		02582	15366
Ensembl ID		ENSG00000117724	ENSG00000170385
Uniprot IDs		A0A9L9PXU7 P49454	Q9Y6M5
PDB IDs		Not available	8J2G 8XM6 8XMA 8XMF 8XMJ 8ZB0 8ZSB 8ZSZ
GO Terms Enriched among Interactors		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion	Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Ciliary Transition Fiber Pronucleus G Protein-coupled Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Kinetochore Assembly Outer Kinetochore Dynein Complex Binding Ventricular System Development Kinetochore Organization Mating Behavior Hormone Binding Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Reproductive Behavior G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Regulation Of Striated Muscle Tissue Development Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Insulin Secretion Regulation Of Muscle Organ Development Negative Regulation Of Peptide Secretion